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Effect of low-choelsterol diet on lipid parametrs by patients with hypercholesterolemia
Šilerová, Tereza ; Zlatohlávek, Lukáš (advisor) ; Šnejdrlová, Michaela (referee)
This Bachelor thesis is focused on dyslipidemia, as a significant risk factor in terms of the occurrence and development of cardiovascular diseases. It describes the various lipids found in blood plasma. It explains the concept of dyslipidemia, their classification, diagnosis and therapy, which involves pharmacotherapeutic treatment and dietary measures as recommended for these diseases. It touches upon the process of atherosclerosis, as there is a very close between atherosclerosis and dyslipidemia. It gives a detailed description of the principles of the diet recommended for patients with hypercholesterolemia. The practical part of the work is devoted to research focusing on patients with hypercholesterolemia in order to determine their eating habits and the influence that a low-cholesterol diet has on blood lipid parameters. The aim was to either confirm or refute hypotheses concerning dietotherapy. The purpose of this work is to stress the importance of thorough and repeated education for patients in order to help prevent the occurrence and development of cardiovascular diseases. Keywords: dyslipidemia, atherosclerosis, diet therapy, education, prevention
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Influence of Diet on Blood Lipid Levels in Dyslipidemic Patients
Dostálová, Lenka ; Zlatohlávek, Lukáš (advisor) ; Šnejdrlová, Michaela (referee)
The bachelor thesis is focused on the relationship of eating habits and dyslipidemia. Its aim is to find out whether diet influences blood lipid levels. The paper is divided into a theoretical and a research part. The theoretical part handles with lipids of the human organism in general, their metabolism and the risks of atherosclerosis. The research part describes work with patients who suffer from lipid metabolism disorders. The patients had a diet consultation and, two months after, they had their blood drawn to see the results of cholesterol and triglycerides levels. The patients also filled in a questionnaire concerning their eating habits. It turned out that nutritional intervention had resulted in an average decrease in triglycerides and total as well as LDL-cholesterol levels. However, HDL-cholesterol level decreased as well. Furthermore, the questionnaire enquiry showed that dyslipidemic patients do not, in general, disobey recommendations of the dyslipidemic diet. The results of the paper showed that dyslipidemic patients follow recommendations of a healthy diet. However, there is still space for improvement. Thus, regular diet consultations are important and can help improve state of health of dyslipidemic patients. Keywords: Diet, dyslipidemia, cholesterol, triglycerides
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Relationship of apolipoprotein E polymorfism on the functional fitness in the elderly
Šnejdrlová, Michaela ; Češka, Richard (advisor) ; Hubáček, Jaroslav (referee) ; Zadák, Zdeněk (referee)
(EN) Background: The life expectancy is defined by a combination of genotype (25%) and environmental influences, including lifestyle (75%). Nevertheless a stronger genetic influence is expressed in long-living individuals. Epsilon gene for apolipoprotein E (APOE) belongs among the most studied so called "candidate genes of longevity". The association of APOE polymorfism is proved in relation to many diseases (hypercholesterolaemia, cardiovascular disease, Alzheimer disease), thus we tried to evaluate the relation of APOE polymorfism and senior fitness. Methods: In our pilot study we examined a total number of 128 patients (93 women, 35 men), all of them older than 80 years, average age 88.6 ±5.3 years. Examinations: A) detailed examination of functional fitness (ADL, MMSE, Yeassavage's depression scale , MNA, 6-MWT). Based on this complex examination, patients have been sorted to 5 functional categories according to W. Spirdus, these categories objectively express the level of self - sufficiency. B) laboratory examinations C) examintaion of APOE gene polymorphism using DNA restriction analysis, DNA isolated from peripheral leucocytes Results: Our pilot study proved statisticaly significant relation (p = 0,0248) between allele E4 and functional fitness in senior age. According to the results of...
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