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Investigating very high-frequency oscillations phenomena in human brain
Kolajová, Martina ; Cimbálník, Jan (oponent) ; Klimeš, Petr (vedoucí práce)
The identification of the seizure onset zone (SOZ) -- the area of the brain where the seizure originates -- is critical for the success of epilepsy surgery. The significance of very high-frequency oscillation (VHFO) is based on their role as a more specific biomarker for this disease, although the mechanism of their generation remains unclear. Individual neurons are not capable of generating oscillations in the range of VHFO. Therefore, it is assumed that VHFO, detected by macroelectrodes, may arise from the summed activity of various neuronal subgroups firing asynchronously. This master's thesis provides thorough information on the matter of VHFO phenomena with a particular focus on their relationship to epilepsy. Through methods such as the utilization of microelectrodes (MEA), this thesis investigates mechanisms behind VHFO generation and presents its findings through data analysis in the programming language Python.

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