Národní úložiště šedé literatury Nalezeno 2 záznamů.  Hledání trvalo 0.00 vteřin. 
Enzymes of Purine Salvage Pathway in \kur{Trypanosoma brucei} and the Trypanocidal Action of Acyclic Nucleoside Phosphonates
KOTRBOVÁ, Zuzana
This study aims to functionally characterize two enzymes, HGPRT and XPRT, of an essential purine salvage pathway in the infection stage of Trypanosoma brucei. Localization, in vivo function and in vitro activity of these enzymes were characterized. Effect of acyclic nucleoside phosphonates, putative inhibitors of HGXPRT, on the viability of bloodstream form of T. brucei was evaluated.
Cytotoxicity screen of the acyclic nucleoside phosphonates against bloodstream stage of \kur{Trypanosoma brucei} and validation of their putative target hypoxanthine/xanthine/guanine phosphoribosyltransferase
MITTERMAYR, Martina
The aim of this study was to test several compounds of acyclic nucleoside phosphonates (ANPs), which are thought to inhibit the purine salvage pathway enzyme hypoxanthine/xanthine/guanine phosphoribosyltransferase (HGXPRT) of the bloodstream stage of Trypanosoma brucei. Further we intended to elucidate if HGXPRT enzymes are essential for the survival of the bloodstream T.brucei.

Chcete být upozorněni, pokud se objeví nové záznamy odpovídající tomuto dotazu?
Přihlásit se k odběru RSS.