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Národní úložiště šedé literatury Nalezeno 1 záznamů.  Hledání trvalo 0.00 vteřin. 
Bioengineering testing of the human skin and the use of cosmetic products
 Freudlová, Michaela ; Omelková, Jiřina (oponent) ; Zemanová, Jana (vedoucí práce)
The skin protects the organism against the penetration of micro-organism and chemical substances. The skin is a complex of four compartments: the epidermis, the dermo-epidermal junction, the dermis and the hypodermis. The Stratum corneum (SC) is the outermost layer of the epidermis and plays an important role in the dermato-cosmetic science. The SC is composed of protein-enriched corneocytes embedded in a lamellar lipid bilayer. The intactness of the lipid bilayers to corneocytes is presented as barrier function of the skin. The barrier of the SC is not perfect. The water from deeper highly hydrated layers can diffuse to the surface. This flux of the water is called Transepidermal water loss (TEWL) and can be measured. The measurement of TEWL is a non-invasive bioengineering method for assessing the skin barrier function. The hydration of the SC can be assessed by non-invasive bioengineering methods as well. These methods are based on the electrical properties of the skin. This thesis deals with an assessment of the hydration of the skin, the skin barrier function and the comparison of instruments. Different types of instruments were used for measurements. The Tewameter TM 210 measures the gradient of water vapour above the skin surface, the Skicon 200-EX measures electrical conductance, the Corneometer analogical CM 825 and Corneometer digital CM 825 measure electrical capacitance. The bioengineering measurements were carried out before any treatment of the skin and after some specific treatments such as application of specific products or stripping with adhesive tape. From gained results it is possible to claim that the TEWL increased after stripping and the hydration of the skin increased after application of moisturize products. Comparison of instruments was assessed by the Pearson correlation coefficient. The correlation coefficients were positive and significant, that means that the two variables were linearly correlated.
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