|
|
Advanced Methods for Genome Annotation and Functional Description of Non-Model Organisms in Biotechnology Research
Musilová, Jana ; Friedel, Caroline (oponent) ; Šafránek,, David (oponent) ; Sedlář, Karel (vedoucí práce)
Comprehensive knowledge of the genome and phenotype of biotechnologically usable bacteria is crucial for their exploitation. However, approaches to a complex understanding of these organisms are widely lacking. The dissertation, therefore, aims to propose novel computational methods for describing the genomic and functional characteristics targeted at non-model bacteria. The initial part of the thesis is focused on the genome annotation methods. Developing a novel pipeline for whole-genome hybrid assembly is included, as well as its application to various bacteria and consequent identification of their genomic regions of interest. Subsequently, functional description methods focused on approaches for studying gene regulation are covered. In detail, the state-of-the-art approaches are reviewed, and the development and testing of a package for gene regulatory network and Boolean network inference are presented.
|
host ::
RSS.