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Computational modeling of the interaction of flowing blood with the artery tube with the atheroma
Freiwald, Michal ; Jagoš, Jiří (oponent) ; Švancara, Pavel (vedoucí práce)
This master’s thesis deals with the interaction between flowing blood and an atherosclerotic carotid artery using a finite element fluid-structure interaction analysis. In the first part, a summarized theoretical background is introduced, consisting of cardiovascular system, blood vessels, corresponding constitutive models, blood rheology, and fluid flow theory. Next, a brief summary of the current state of computational modeling in this area is provided, mainly focusing on structural and fluid-structure interaction analyses, and the types of constitutive models used. Experimental part focuses on the creation of a simplified model of the internal carotid artery with an atherosclerotic plaque, and a corresponding model of blood in this artery. Both models are afterwards used to perform a fluid-structure interaction analysis to understand the consequences of a pulsatile blood flow on the artery wall and atherosclerotic plaque growth; primary characteristics of interest are the first maximum principal stress on the artery wall and its deformation, wall shear stress and its corresponding time-averaged value, and oscillatory shear index. All results are compared across several different analysis types, to assess the differences and impact of a chosen approach. A simplified parametric study is also performed, to determine the impact of the stenosis percentage on resulting characteristics. Lastly, results, limitations of this thesis, and possibilities of further research are discussed.
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Computational modeling of the interaction of flowing blood with the artery tube with the atheroma
Freiwald, Michal ; Jagoš, Jiří (oponent) ; Švancara, Pavel (vedoucí práce)
This master’s thesis deals with the interaction between flowing blood and an atherosclerotic carotid artery using a finite element fluid-structure interaction analysis. In the first part, a summarized theoretical background is introduced, consisting of cardiovascular system, blood vessels, corresponding constitutive models, blood rheology, and fluid flow theory. Next, a brief summary of the current state of computational modeling in this area is provided, mainly focusing on structural and fluid-structure interaction analyses, and the types of constitutive models used. Experimental part focuses on the creation of a simplified model of the internal carotid artery with an atherosclerotic plaque, and a corresponding model of blood in this artery. Both models are afterwards used to perform a fluid-structure interaction analysis to understand the consequences of a pulsatile blood flow on the artery wall and atherosclerotic plaque growth; primary characteristics of interest are the first maximum principal stress on the artery wall and its deformation, wall shear stress and its corresponding time-averaged value, and oscillatory shear index. All results are compared across several different analysis types, to assess the differences and impact of a chosen approach. A simplified parametric study is also performed, to determine the impact of the stenosis percentage on resulting characteristics. Lastly, results, limitations of this thesis, and possibilities of further research are discussed.
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