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Quantitative computed tomography
Šalplachta, Jakub ; Keckes, Jozef (oponent) ; Batenburg, Joost (oponent) ; Kaiser, Jozef (vedoucí práce)
The main aim of this thesis is to study, explore and possibly move further the field of quantitative computed tomography (QCT) with specific focus on a laboratory-based submicron computed tomography (CT) system Rigaku nano3DX. This work is dealing with both aspects of the QCT, which are the acquisition of quantitative CT data and the utilization of CT data for quantitative analysis. Regarding the first aspect, specific focus is placed on assessment of current technological limits of submicron CT, where the technology-based tomographic artifacts are studied, and optimal reduction strategies are proposed. Also, practical aspects related to implementation of spectral CT in a form of dual-target CT (DTCT) using Rigaku nano3DX system, are solved by development of dedicated acquisition and data registration methodologies. For the quantitative analysis of CT data, two novel methods were developed. One was specifically designed for porosity analysis of additive manufactured samples with a respect to the crucial points of tomographic data processing, making it objective and reproducible. Second method was specifically designed for quantitative assessment of 3D models of biological tubular systems and was practically tested on a mouse model of Alagille syndrome.
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