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Circadian rhythm of parathyroid hormone and bone remodeling: implication for the osteoporosis treatment with teriparatide (parathormone [1-34])
Rašková, Mária ; Zikán, Vít (advisor) ; Žofková, Ivana (referee) ; Perlík, František (referee)
Circadian rhythm of parathyroid hormone (PTH) is well documented, but its physiological role is not fully understood. In healthy individuals, biochemical markers of bone remodeling follow a similar circadian rhythm to PTH with a nocturnal rise in bone resorption and formation. The loss of PTH diurnal variation was observed not only in primary hyperparathyroidism, but also in patients with postmenopausal osteoporosis. Continuously elevated concentrations of PTH lead to excessive stimulation of bone resorption, whereas intermittent PTH administration has a strong osteoanabolic effect in patients with osteoporosis. It has not been examined whether the skeletal sensitivity to PTH action depends also on the time of its application. The aim of our study was to verify the hypothesis that the application of teriparatide (TPTD, recombinant human PTH [1-34]) at different times of the day in the context of its diurnal variability affects the physiological circadian rhythm of bone remodeling and also the bone mineral density (BMD) after the long-term TPTD treatment. Fourteen women with postmenopausal osteoporosis treated with 20 micrograms of TPTD daily, applied subcutaneously either in the morning or evening, were included in the first study. The concentration of serum C-terminal telopeptide of type I collagen...
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The effect of the blue light on the human body
Dvořák, Petr ; Krbal, Michal (referee) ; Štěpánek, Jaroslav (advisor)
This thesis explains the term „blue light“. It deals with the sources of blue light and the effects of this type of electromagnetic radiance on human body. The focus is concentrate especially on problems, which are evocated of blue light. The biggest danger is the desynchronization of circadian rhythm and photochemical damage of retina – photoretinitis („blue light hazard“). The basic principles of biological processes and the visual system are described here. These processes are controlled by properties of incident light onto the retina of eye. The basic information about artificial sources of blue light commonly used in households and in industry are mentioned in the second half of work. These light sources were measured and elaborated. The electromagnetic spectrums of sources are portrayed and there is a comparison of sources due circadian effect too.
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Comparation of circadian rhytms in teenagers at a comprehensive school and a specialized vocational school
KRATOCHVÍLOVÁ, Lenka
BACKGROUND:The aim of this thesis is to monitor from a professional point of view the area of health, healthy lifestyle, circadian rhythms, eating habits and free time activities in teenagers of today. Main focus is put on the sleeping regime which has enormous effect on behaviour and health of individuals and is closely connected to other biological rhythms. OBJECTIVE: The thesis aims to compare students at two different types of school, to give guidance in the area of health education during the process of form-filling as well as contribute to the formation of the students with regard to health, mental, physical and social sphere. Another purpose of this thesis is also to monitor health habits of this age group and possibly those of their families. METHOD: The method applied for the research was a set of questionnaires. Total number of respondents was 40 students of a comprehensive school and 40 students of a specialized vocational school in the age span between 15 to 17 years of age. Presentation of the study field "Health education" was given due to the students´ interest and space was given to their questions. Health education exists and is practically implemented in both types of schools. RESULT: Comparation between the two schools proved there are significant differences in sleeping regimes, eating or spending free time. Also it has been proven that most respondents suffer from lack of sleep and tend to shift sleep to later hours. CONCLUSION: Students were found to have serious violations of healthy habits including sleeping and eating. More emphasis should be put on teaching young people about the importance of adjustment to circadian rhytms and explanation how they would benefit from adhering to the natural rhytms.
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