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Optimalization of Routes for Travel Agencies
Sieberová, Tereza ; Kučera, Petr (advisor) ; Mudrychová, Kristýna (referee)
This Bachelor thesis Optimization of Routes for Travel Agencies deals with the solution of a circular transport system problem, based on the information from a travel agency. The first part of the thesis is dedicated to a literary recherche about this issue, and basic concepts and individual methods, which can be used for optimization of routes, are explained here. The second part briefly describes a travel agency and a selected tour, which is then optimized through selected methods, in order to find a route, which ensures the lowest costs. The end of the work deals with evaluation of the result and suggesting more convenient solution of the trip.

Optimization of Routes for Public Transport
Neumarová, Andrea ; Kučera, Petr (advisor) ; Fejfar, Jiří (referee)
This bachelor thesis, Optimization of Routes for Travel Agencies, deals mainly with traveling agency problem and its optimization for a specific travel agency. For the purposes of this research, the author has chosen routes from Václav Haver International Airport to several hotels from Prag area - Andel's Hotel Prague, Art Deco Imperial Hotel, EA Hotel Jasmín, Hotel Fortuna Rhea, InterContinental Prague, Orea Hotel Pyramida Praha, Panorama hotel Prague. The main object is to examine which of the selected tours are economically optimized (by costs). The theoretical chapter is focused to the distribution tasks as well as methods, whose application leads to the optimization of the routes. The practical chapter includes the modificated nearest neighbor method, and the Vogel approximation method. To illustrate the application of heuristic methods the calculation is carried out by savings method, too. In conclusion, the obtained results are evaluated and suggestions made for a more economic solutions of the routes examined

Optimalization of Routes for Travel Agencies
Král, Filip ; Kučera, Petr (advisor) ; Mudrychová, Kristýna (referee)
The bachelor´s work devotes to solving travelling salesman problem for transport company Gumdrop s. r. o., which organizes tours to Croatia and Italy. There is a literacy research in the first part of bachelor´s work, which is focused to explanation of approximations methods. There is a short introduction of transport company in the beginning of the second part. Two foreign travelling salesman problems and one gathering route in the Czech Republic were solved for this company. The ending part interprets results, which were presented in transport company. There is their reaction also.

Optimization of Transportation Routes between a Chosen Company and Its Clients
Kolka, Michal ; Kučera, Petr (advisor) ; Temirkhanov, Maxat (referee)
This bachelor thesis deals with optimization of traffic routes, that is particularly regular supplies of the Almms s.r.o. company. In the theoretical part, there is explained the term of logistics. The next topic is graph theory, which is important for demarcation of the rest of the theoretical part. Main part of the work is a Travelling Salesman Problem, which is specified in the thesis including the use of approximation methods. The Multi-circuit transport problem is associated with the topic as well. The solution of this task is to put together a specific circuit tasks. In the last part of the thesis, there is the processing of a specific problem itself on a chosen subject. Then follows the detailed analysis of the established routes. In the beginning, there are created the circuit routes with the using of Mayer´s method and then there are applicated approximation methods on the new gained circuits for their optimization. From the obtained results, there is a conclusion, picking of a new obtained routes and comparison them with the established ones.

Optimization of Routes for Delivery Services Firms
Jindra, Tomáš ; Kučera, Petr (advisor) ; Pavlíčková, Petra (referee)
This bachelor´s thesis deals with the optimization of routes for delivery services firms. The thesis consist of a theoretical and a practical part. The theoretical part explains the concepts of logistics, logistics chain and travelling salesman problem with optimization methods used in the practical part. In the practical part three routes for delivery service firm Zásilkovna.cz are optimized by the nearest neighbour method, Vogel approximation method and savings method. In the end the results are compared in the lenght of routes and financial savings.

Optimization of Transportation Routes between a Chosen Company and Its Clients
Mazánek, Tomáš ; Kučera, Petr (advisor) ; Petr, Petr (referee)
The subject of this diploma thesis titled "Optimization of Transportation Routes between a Chosen Company and Its Clients" is the logistic routes optimization of the selected company, which is in thesis case company MITRANS - HK s.r.o. From company routes portfolio all circle routes are selected, which are lately solved by different methods, which are used for traveling salesman problem. Then the provided results are evaluated and compared between themselves and between real used routes variants. The thesis also handle the economic efficiency of optimization, which is presented on solved routes.

Optimization of delivery precincts routes
Suchý, Pavel ; Kučera, Petr (advisor) ; Houška, Milan (referee)
The aim is to optimize the selected route for the given Czech Post Office. For the purpose of optimization approximation methods - focusing primarily to minimize the total distance and costs of their own transportation were used. According to the amount of input data, which was avalaible, the optimation model cases (examples) in the system of contracting authority were evalueted. The success of each method was compared, and the software solution was done.

Optimization of travel agency routes
Ötwösová, Karolina ; Kučera, Petr (advisor) ; Pavlíčková, Petra (referee)
Summary This thesis deals with the optimization of chosen travel agency routes. The optimization is performed using several methods, e. g. nearest neighbor method, Vogel approximation method and spanning tree method. For each method a comparison is provided with the original route and map, which illustrates visited places and their distribution. The theoretical part describes the origin of tourism, the Czech republic in international tourism, legislation and logistics. In this section the methods of the analytical part and their advantages and disadvantages are described. In the final part of the work all the information obtained using the above methods are included in the final discussion and there the best method for chosen travel agency is featured.

Molecular mechanism of hydrogen sulfide action during meiotic maturation of porcine oocytes
Veselá, Andrea ; Hošková, Kristýna (advisor) ; Tomáš, Tomáš (referee)
At present reproductive biotechnology methods are on the rise, but their development and application in the broader management of reproduction is dependent on obtaining a sufficient number of quality oocytes cultured in vitro. The prerequisite for this requirement is the creation of the optimal conditions in the course of culturing oocytes. Understanding and knowledge of the processes that occur in oocyte during maturation is an important and necessary condition for optimizing the process of culturing oocytes in vitro and gaining a sufficient number of good quality oocytes in metaphase II of meiotic division. A large number of mechanisms that affect and control oocyte maturation are known, however it cannot be claimed that this process has been fully explained and studied. One factor which has a potential role in the regulation of meiotic maturation of oocytes is gasotransmitter hydrogen sulfide (H2S), a critical signaling molecule of endogenous origin. The study of H2S led to the hypothesis that H2S actively influences the course of meiotic maturation of pig oocytes by regulating key signaling cascades. The aim of this work was to determine the involvement of H2S in the regulation of the MEK1-MAPK signaling cascade, responsible for the initiation and progress of the meiotic maturation of oocytes and the MEK1-PARP-1 cascade as signaling that supports cell viability. For this purpose, pig oocytes cultured in modified media were used, supplemented with a specific combination of enzyme inhibitors (3Ki) or in a culture medium with donor H2S. The ocytes were then subjected to immunocytochemistry staining, fluorescence microscopy and image analysis. The results show that H2S is involved in the regulation of meiotic maturation. It confirmed the hypothesis of the endogenous production of H2S in the course of the meiotic maturation of pig oocytes and the influence of the MAPK signaling cascade. Based on the results, it is however likely that the MEK1-PARP-1 signaling cascade is not affected by H2S, unlike MAPK signaling, comprising the mentioned MEK1 as superior kinase. MAPK kinase activity is significantly lower in oocytes after treatment 3Ki. Further experiments are for a detailed understanding of these regulatory pathways and for the proper verification of the mechanism of the effects of H2S necessary, in particular for a full understanding of the target control factors by the post-translational modification of S-sulfhydration.

Optimization of Accounting Treatment of Lease in Czech Company as Part of Consolidated Group
Dohnalová, Eliška ; Stárová, Marta (advisor) ; Kamila, Kamila (referee)
The diploma thesis deals with optimization of accounting treatment for operating leases in Czech company which is obliged to provide data for financial statements prepared in accordance with US Generally Accepted Accounting Principles (US GAAP) and is concurrently is subject to the legislation of the Czech Republic. In theoretical part is characterized term leasing and it´s accounting treatment in accordance with legislation of the Czech Republic. The accounting treatment under US Generally Accepted Accounting Principles (US GAAP) is defined by using of available literature resources. In the practical part is first introduced selected company. For the purpose of this thesis was selected IT company XEROX CZECH REPUBLIC Ltd., which provides printing solutions for all kinds of business. After that the practical part analyzed the leasing process of the company and on the basis of the facts are presented proposals for process optimization and accounting treatment of leasing.