National Repository of Grey Literature 46 records found  beginprevious41 - 46  jump to record: Search took 0.01 seconds. 
Comparative study of the drug effect on selected disease based on the human genetic polymorphisms
Beňková, Daniela ; Sekorová, Šárka (referee) ; Cicková, Pavlína (advisor)
This bachelor thesis is dealing with topic of effects of medicine from the viewpoint of the genetic polymorphism occurrence in human being. The main targets of my bachelor thesis include describing the pharmacogenomics as a scientific branch, single nucleotide polymorphisms and methods of their searching, providing information about Alzheimer’s disease, looking up the medicine for the treatment of this disease, comparing their effects, describing pathways and realizing ADMET profiling of these drugs and evaluating data.
Variabilita markeru TG5 a asociace k obsahu intramuskulárního tuku a marblingu u skotu
Grosová, Hana
The variability of the marker TG5 TG gene and its association with the intramuscular fat and marbling of meat in cattle was studied. Randomly selected population, composed of 237 individuals (bulls) of the Czech Pied cattle breed from four farms in the Czech Republic, waschosen for testing polymorphisms. Polymerase chain reaction was used to amplify a fragment of TG 545 bp in size. After amplification, the fragments digestion was performed using the restriction endonuclease BstYI. To verify the presence of the PCR product and to identify the sizes of digested frag-ments the horizontal agarose electrophoresis was performed. The population's absolute and relative frequencies of alleles and genotypes were calculated. The calculations reve-aled a high frequency of the T allele (25.98 %). In conclusion, statisticalanalysis was performed. As a result, the influence of C422T polymorphism in the 5'promoter region of the gene on the TG and on the IMT marblinghave not been proven, but on the contra-ry there was detected significant effect (p<0.05) of polymorphism content on the region of Lauric acid (C12:0). The results also reveal some evidence of polymorphism having influence on Timnodonic acid and meat pH.
Slovak National Uprising
Orság, Michal ; Terén, Laco (referee) ; Ambrůz, Jan (advisor)
The aim of the thesis was to bring events after 1945, when there was a period of remembrance in the company , which served as a therapy , politics and aesthetics . Work on the memories gradually morphed into , among other things , to the monuments that act against collective oblivion . Arise place of remembrance , which relate to historical events and private stories . Partisan monuments fill in the country which they have to remind essentially absent . Again remembering you and gets to the surface again forgotten information that creating a logical connection form the structure . This structure is subject to change , which helped by rewriting and overlapping information in different layers of the structure . Neither art does not avoid the remembrance and forgetting , and creates a theme of a strategy , which is included rewriting . Media and individual override blank sheets in the past, currently , collecting and composing the mosaic , which allows you to create your own identity.
SNP identification for genetic mapping of CpGV resistance in codling moth, \kur{Cydia pomonella}.
PROVAZNÍKOVÁ, Irena
Codling moth (Cydia pomonella) is a major pest of pome fruit and walnuts in the world. Cydia pomonella granulovirus (CpGV) is used as a highly efficient and specific way to control this pest. Recently, several resitant populations have been reported. This thesis presents literature survey of codling moth genetics and CpGV resistance. It also provides experimental design for linkage mapping of codling moth resistance to CpGV.
Molecular genetic analysis of virulence factors from Streptococcus pneumoniae
KVARDOVÁ, Kristýna
The work focuses on the significance of pneumolysin in contribution to virulence of Streptococcus pneumoniae serotype 1 isolates. Methods include bioinformatics as well as in vitro assays. A SNP within nucleotide sequence of the second virulence factor, hyaluronidase, is a subject for screen of meningitis isolates.

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