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Presence of tick-borne encephalitis in Pribram district with its level of awareness and general attitude to vaccination against it in selected populations
KUCHAŘOVÁ, Eliška
Central European tick-borne encephalitis is a disease belonging to the group of zoonosis, which is transmitted by the tick Ixodes ricinus. It is an acute neuroinfection caused by the RNA virus that can seriously endanger people?s lives. Tick-borne encephalitis is one of the diseases typical for its natural pocket. The most common way of transmission onto a human being is by the bite of an infected tick. However, there have been cases where the contagion took place by consuming unpasteurized milk or dairy products. Although it is a disease which can be easily prevented, vaccination is still very low in our country. If we do not press people to improve this situation, we can expect frequency of tick-borne encephalities will be increased.
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The role of genetic background of the host on the pathogenesis of tick-borne encephalitis
PALUS, Martin
We examined the influence of the host genetic background on the pathogenesis of tick-borne encephalitis. We determined virus titers in organs and serum in different time intervals post-infection for different ways of inoculation. We also stated mean survival times and antibody production in different strains of mice infected with tick-borne encephalitis virus. Moreover, differences in expression of immunologicaly important genes in brains of infected mice were compared.
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Awarness of Public of Tickborne Encefalitis Infection
VOKROUHLÍKOVÁ, Monika
In my bachelor work I monitor the awareness of the general public on the tick-borne encephalitis and the attitude of the general public to vaccination against this disease. I have found out using research that the population is aware of the tick-borne encephalitis but the population is not interested in vaccination against the disease.
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Cultivation of tick-borne encephalitis virus in the presence of inhibitor of glycosylation: its effect on nucleotide sequence of genes encoding viral proteins.
FARKOVÁ, Karolína
In this work I compared nucleotide sequences of virus genes and the resulting aminoacid sequences of viral proteins of TBE virus variant Hypr3TM with the parental virus Hypr50/CB. This comparison serves for identification of nucleotide/aminoacid substitutions resulting for virus replication in an enviroment with inhibited protein glycosylation. I identified four nucleotide substitutions; three of them caused also changes in amino acid sequence. When compared to a low-passaged variant Hypr5, three of the nucleotide substituions were identical with this variant. One amino acid substitution is unique for variant Hypr3TM. This substitution caused changes in electrostatic potencial of receptor domain of protein E and thus can affect the protein-protein interactions within homodimers and homotrimers at the surface of the protein and the interaction of the E protein with host-cell receptors for the TBE virus.
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