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The role of Arachidonic acid metabolites in cardiovascular system and signaling of heart failure
Liptáková, Andrea ; Žurmanová, Jitka (advisor) ; Holzerová, Kristýna (referee)
Arachidonic acid (AA) is polyunsaturated acid that plays an important role in regulation of physiology, bioenergetic and signalling cascades in the heart. AA released by phospholipase A2-catalysed hydrolysis of membrane phospholipids serves as substrate for cyclooxygenase, lipooxygenase and cytochrome P450 epoxygenase to produce a wide spectrum of lipid second messengers, eicosanoids. These very biologically potent molecules regulate a number of cellular processes in the cardiovascular system and changes in their composition and concentration significantly contribute to heart failure. The aim of this thesis was to summarize current knowledge about the role of AA in failing heart. Keywords : Heart, Arachidonic Acid, Heart Failure, Eicosanoids, Cardiovascular System
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The effect of sauna on the changes of blood pressure
Benko, Michal ; Bunc, Václav (advisor) ; Heller, Jan (referee)
Title: The effect of sauna on the changes of blood pressure Objectives: The aim of this study was the measure of the physiological range (blood pressure, heart rate, blood oxygen saturation) of two selected groups of people within the sauna cycle, assess changes and compare the results of individual probands and groups. Methods: This thesis is conducted as an experimental study. This is a quantitative method, in that will be at first established hypotheses and then evaluated on the basis of the obtained results. The independent variable in this research is the sauna and dependent variables are blood pressure, heart rate and blood oxygen saturation. Results: Blood pressure values were at employee of sauna lower than at other probands, thereby was confirmed hypothesis, but expected significant differences between the measured values of each group were absent. At the same time there was a further confirmation of the hypothesis concerning heart rate, which was increased at all probands. The last confirmed hypothesis related to the blood oxygen saturation and its reduce after the sauna. It could be said that all the defined hypotheses were confirmed. Keywords: sauna, blood pressure, heart rate, blood oxygen saturation, cardiovascular system
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The effect of sauna on the changes of blood pressure
Benko, Michal ; Strejcová, Barbora (advisor) ; Bunc, Václav (referee)
Title: The effect of sauna on the changes of blood pressure Objectives: The aim of this study was the measure of the physiological range (blood pressure, heart rate, blood oxygen saturation) of two selected groups of people within the sauna cycle, assess changes and compare the results of individual probands and groups. Methods: This thesis is conducted as an experimental study. This is a quantitative method, in that will be at first established hypotheses and then evaluated on the basis of the obtained results. The independent variable in this research is the sauna and dependent variables are blood pressure, heart rate and blood oxygen saturation. Results: Blood pressure values were at employee of sauna lower than at other probands, thereby was confirmed hypothesis, but expected significant differences between the measured values of each group were absent. At the same time there was a further confirmation of the hypothesis concerning heart rate, which was increased at all probands. The last confirmed hypothesis related to the blood oxygen saturation and its reduce after the sauna. It could be said that all the defined hypotheses were confirmed. Keywords: sauna, blood pressure, heart rate, blood oxygen saturation, cardiovascular system
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The measurement of cardiovascular parameters
Žáková, Monika ; Kratochvíla, Jiří (referee) ; Nováková, Zuzana (advisor)
This paper summarizes the problems of physiology of the cardiovascular system, with a focus on cardiovascular measurements during physical activity. It describes the diagnostic tools Cardiovit AT-104 (Schiller, Switzerland) and PowerCube (Ganshorn, Germany), used to spiro-ergometry measurements. It provides options to export data and work with them. It proposed protocol for the measurement of a small group of volunteers, by which we measure basic diagnostic parameters before, during and after physical activity. The MATLAB application is created, allowing clear analysis of measurement records. The final part contains a statistical assessment affected by physical activity on the measured parameters and a comparison of results with the available literature.
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Medical standing devices
Vadják, Šimon ; Ronzhina, Marina (referee) ; Kolářová, Jana (advisor)
This bachelor‘s thesis deals with patient verticalization and medical standing devices, which we use for this purpose. These findings are particularly important for rehabilitation and nursing care and also for the development of new standing devices. The bachelor‘s thesis describes the basic con¬cepts of human motor skills, the effect of changing position on the human organism, an overview of medical standing devices and their comparison. Thesis deals with comparison of the technical pa¬rameters of two standing devices more closely, standing device BALANCE Trainer and STOJ. The final part is devoted to measuring blood pressure using the noninvasive, continuous method of measuring at a group of wheelchair users during verticalization. I created a program with a graphical interface which allows measured data to load, display and measure, in numerical compu-ting environment MATLAB (version 7.9.0-R2009B). The results were statistically tested in the same numerical computing environment.
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Continuous measurement of blood pressure
Kopčil, Petr ; Chmelař, Milan (referee) ; Nováková, Zuzana (advisor)
This paper deals with the physiology of cardiovascular system, explains elementary principles related to blood flow physiology and describes some basic mechanisms for regulation and blood pressure measurement. The paper also includes a description of the medical device, known as the Finometer (FMS, Netherlands), for continuous non-invasive blood pressure measurement and suggests a way to data export from this device to a text file. It introduces user friendly application to manage recorded data written in MATLAB. There is a statistical test to assess the difference between two statistical data files in the last chapter of this paper which includes a comparison our results with studies made in Czech Republic and other countries too.
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Influence of the surrounding tissue on the stresses in brain arterial aneurysms
Lipenský, Zdeněk ; Burša, Jiří (referee) ; Polzer, Stanislav (advisor)
This thesis is focused on stress in brain aneurysms. It consists of three parts. First part is aimed for gaining information about the topic from scientific resources. Next part consists of analyses of geometry of cerebral aneurysms on the computed wall stress. Analyses are performed on four basic geometrical models and results are being discussed. The risky areas in each investigated shape have been identified as well as the comparisons of stress between those shapes have been performed and the most dangerous shape among investigated shapes has been determined. Third part investigates the influence of surrounding tissue on the brain aneurysm. Conclusion of this thesis is that brain gray tissue has positive yet negligible effect on the computed wall stress.
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Measurement of cardiovascular parameters
Kratochvíla, Jiří ; Čmiel, Vratislav (referee) ; Kolářová, Jana (advisor)
The aim of the bachelor’s thesis is to get acquainted with the measurement of cardiovascular parameters, to realize the measurment of these parameters, to analyze them, show the statistic procedure of verifying hypotheses in this spere and finally the presentation of measured data including automatical detection of the heart rate from ECG signal in created program in Guide of Matlab system. On the basis of the theory was done the measurment on own suggestion with the Biopac system and with the quicksilver tonomether. The parameters, that were measured on the group of five people: ECG, blood pressure and the pulse frequency before and after the load. After the data processing was done the statistic analysis, the aim of this analysis was to show the procedure of verifying hypothesis, if and how are these measured parameters of cardiovascular system changing. After that the measured data were transported into Matlab system. The presentation of measured data (created program) contains the time domain and spectral analyses (using Fourier transform) of ECG signal, automatical detection of the heart rate from ECG signal, analysis of the heart rate variability (HRV) – tachogram together with detailed analysis of HRV spectra (spectra of heart rate variability – relating with parasympathetic and sympathetic activity), that are using in clinical practice too, just as the other measured parametres of the cardiovascular system.
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Literature search of possibilities of computational modelling of brain aneurysms
Lipenský, Zdeněk ; Polzer, Stanislav (referee) ; Burša, Jiří (advisor)
This bachelor thesis is focused on gathering general information about a cerebrovascular disorder called Cerebral Aneurysm (or also Brain Aneurysm) which is a medical condition consisting in an abnormal bulging outward of one of the arteries in the brain. The initial attention is given to the human cardiovascular system, a description of which is fatal for understanding the problem of brain aneurysm. The next attention is focused on the solution of eliminating the tension within the aneurysm by using knowledge gained in lectures "Flexibility and Strength II" during the sixth semester. The last chapter shows a summary of three works dealing with computational modeling of cerebral aneurysm.
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