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Measurement of temperature characteristics of resistivity of Cu bulk
Bartušek, Karel ; Fiala, P.
This contribution brings results of numerical modeling during design of measurement method for determine of thermal characteristic of specific resistance of Cu bulk. Combine of numerical modeling and experimental verification brings very effective procedure during suggestion and application in cryogenic region. Result of this work are used in research activities of Czech Academy of Science, ISI-Brno.
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Circuit resistance modeling in failing heart rotary pump support
Musil, Jan ; Pražák, Josef ; Leitermann, D.
The stepwise resistance increase caused by the throttle valve usage in the mock-line circuit comprising the pulsating ventricle in failing heart modus and supported by rotary pump set up in parallel was studied. It appears thus important to regulate support system producing a continuous type of flow to such a regime not allowing the pulsating flow of the failing heart to disappear and preventing the mean systemic pressure value before substantial increase.
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Antibiotics-modes of action, resistance mechanisms and the search for new compounds
Spížek, Jaroslav
According to their mechanism of action antibiotics can be divided into 4 groups. 1. Antibiotics inhibiting bacterial cell wall biosynthesis. 2. Antibiotics inhibiting DNA synthesis. 3. Antibiotics inhibiting RNA synthesis and 4. Antibiotics inhibiting protein synthesis. Basic mechanisms of antibiotic resistance include cell impermeability, modification of target site, modification or degradation of the antibiotic and increased efflux of the antibiotic. The following can be used in the search for new compounds: 1. Microorganisms isolated from extreme life conditions 2. Environmental DNA (eDNA) in which genes coding for secondary metabolites are looked for. 3. Streptomyces genomics yielding information about genes coding biosynthesis of new compounds. 4. Combinatorial biosynthesis for the production of hybrid antibiotics.
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