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Arterial Spin Labeling MRI Data Analyzation
Galanová, Zuzana ; Jiřík, Radovan (referee) ; Krátká, Lucie (advisor)
This bachelor´s thesis is focusing mostly on perfusion imagining, which is done by the method of arterial spin labeling. It describes physical basics of nuclear magnetic resonance, image reconstruction, perfusion imagining without contrast substances, principles of arterial spin labeling and different ways of arterial spin labeling – mostly FAIR-RARE sequence, which belongs to the pulsed arterial spin labeling. One part of the thesis is dedicated to production of perfusion map in Matlab. Results are evaluated by comparison of data produced in Matlab and data produced in Paravision Version 5.1 and they are discussed.
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Contrast MRI perfusion imaging
Šejnoha, Radim ; Harabiš, Vratislav (referee) ; Krátká, Lucie (advisor)
This semestral thesis is focused on contrast MRI perfusion imaging using method of Dynamic Contrast-Enhanced MRI. It describes basic principles of nuclear magnetic resonance and puls sequences used in DCE MRI. The thesis contains a part dedicated to dynamic contrast imaging of phantom with experimental NMR device located at the Institut of Scientific Instruments of the ASCR in Brno. Results of measurements are analyzed based on models and reached perfusion parameters are discussed.
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Modelling for ultrasound perfusion imaging
Hracho, Michal ; Šikner, Tomáš (referee) ; Mézl, Martin (advisor)
This thesis deals with the possibilities of determining perfusion parameters of vascular system, using contrast-enhanced ultrasound imaging, which is non-invasive method. Properties of ultrasonography and use of contrast agents are briefly summarized. The methods selected for perfusions analysis were Bolus-tracking¬¬, Burst-replenishment and both of them combined – Bolus&Burst. Parametric models based on these methods were created for modelling an approximation of set perfusion parameters with the use of blind deconvolution.
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Simulation of pharmacokinetic models
Hejč, Jakub ; Jiřík, Radovan (referee) ; Mézl, Martin (advisor)
The theoretical part of this project is occupied with analysis of pharmacokinetic actions and also basic attributes of mathematical models used in pharmacokinetics. This description is mainly focused on models used for perfusion imaging methods. The aim of this project is to create an algorithm that simulates chosen models based on assigned parameters and also an algorithm that serves to fit experimentally measured data with a chosen model with a calculation of basic pharmacokinetic parameters. The next step of this solution is graphic interface realization which enables a full use of created algorithm in more accessible surroundings for the user. The result of this work is a program that can be used to obtain real data parameters and as well as a visual sample of the influence of these parameters on a process in a chosen functions.
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Compressed sensing in magnetic resonance perfusion imaging.
Mangová, Marie ; Veselý, Vítězslav (referee) ; Rajmic, Pavel (advisor)
Magnetic resonance perfusion imaging is a today's very promising method for medicine diagnosis. This thesis deals with a sparse representation of signals, low-rank matrix recovery and compressed sensing, which allows overcoming present physical limitations of magnetic resonance perfusion imaging. Several models for reconstruction of measured perfusion data is introduced and numerical methods for their software implementation, which is an important part of the thesis, is mentioned. Proposed models are verified on simulated and real perfusion data from magnetic resonance.
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Modelling in perfusion MR imaging
Válková, Hana ; Jiřík, Radovan (referee) ; Kratochvíla, Jiří (advisor)
This thesis deals with the magnetic resonance perfusion data analysis especially DCEMRI. In its introduction the thesis describes the problem of DCE-MRI data aquisition, the necessity of appropriate contrast agent and basic principles of perfusion analysis. The dynamic behavior of contrast agent vascular distribution can be described by arterial input function (AIF). The shape of the curves close to the area of interest is affected by dispersion which is called vascular transport function (VTF) due to the distribution of the contrast agent to the region of interest. Finally the tissue residual function describes system behavior of tissue. The practical part of the diploma thesis is aimed at implementation of model curves AIF, VTF and TRF. Furthermore, a simulation program was created for easy manipulation with introduced models moreover the program is used to perform an estimation of perfusion parameters based on nonblind deconvolution. The method is validated on synthetic data and illustrated on clinical data of the renal cell carcinoma patient.
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Phantom model for perfusion imaging
Borovičková, Michaela ; Harabiš, Vratislav (referee) ; Mézl, Martin (advisor)
This work focuses on issues relating to the perfusion analysis. The aim of this work is to perform experimental measurements of the phantom and then evaluate the perfusion curves. This curves are used to himation of perfusion hemodynamic parameters, which indicates important informatik about monitoring area. All processes associated with the designation and evaluation are performed in a program named Matlab. The output of work is a system that provides the reader into the problem of perfusion analysis and allows him to understand and know what is the meaning od analysis, what demands are placed on the evaluation and what is the result of this perfusion analysis.
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Deconvolution in perfusion imaging
Líbal, Marek ; Havlíček, Martin (referee) ; Bartoš, Michal (advisor)
The purpose of this study is to introduce the methods of the deconvolution and to programme some of them. For the simulation, the tissue homogeneity model and the model of arterial input fiction were used. These models were engaged as the test procedures with the aim of verify the functionality and utility of the Wiener filter, the Lucy-Richardson algorithm and the Singular value decomposition.
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SMV-2015-37: Development of an animal model of septic encephalopathy for MR studies, execution and evaluation of a pilot study
Starčuk jr., Zenon
Two animal models of septic encephalopathy in mice were tested: the induction by lipopolysaccharide, and the fecal model, whose objective was to test their applicability in the study of pathophysiology of septic encephalopathy by magnetic resonance in 9.4 Tesla field. Three MR imaging protocols were optimized: T2-weighted RARE for morphological imaging, protocols for native perfusion imaging ASL, and for contrast-enhanced perfusion imaging DCE applying Magnevist, whose main target was the detection of potential changes in the cerebral blood flow and alteration of the blood brain barrier function. Measurements were performed in Bruker Biospec 94/30 with a set of 27 mice anesthesized by isoflurane, whose physiological functions were continuously monitored. The original and analyzed data were provided to the client.
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Software Package for Ultrasound Perfusion Imaging
Mézl, M. ; Jiřík, Radovan
In this work a Matlab-based software package for perfusion imaging is presented. It is run with a graphical user interface (GUI) and includes five main steps of perfusion analysis. There are applications for data import, image registration, tissue selection, perfusion analysis and visualization. This software has been used for analysis of abdominal ultrasound sequences. It is modular and each module can be easily modified for various methods as well as different image modalities for example magnetic resonance imaging.
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