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National Repository of Grey Literature 12 records found  previous11 - 12  jump to record: Search took 0.00 seconds. 
Xenodiagnosis and its use in leishmaniases research
 Vojtková, Barbora ; Volf, Petr (advisor) ; Svobodová, Milena (referee)
The aim of these theses was to summarize the knowledge about the use of xenodiagnostic methods in the past and their current potential for parasitological research. Xenodiagnosis it is a diagnostic method using bloodsucking arthropods (disease vectors) as a biologic medium suitable for detection of parasites in the blood of investigated individuals (vertebrates). It is expected that parasites grow within the midgut of the vector and then are easily detectable microscopically. The method was used for the first time in 1914 by French researcher Émile Bumpt for detection of Trypasoma cruzi, causative agent of Chargas' disease. During few decades and thanks to engagement of many scientific groups, it became one of the most efficient and effective diagnostic methods. For instance, the most suitable species of vectors, the experiment duration and the optimal numbers of vectors and/or experiments were assigned to get reliable results. Xenodiagnoses as a diagnostic method lost its importance after introduction of molecular methods, first of all after onset of polymerase chain reaction. At present, however, the xenodiagnosis is suitable for experiments studiing if the host is infectious for the vector. This method appears as a good tool for testing of new reservoir hosts and for the monitoring of the role...
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Sensitivity of \kur{Borrelia burgdorferi} sensu lato complex to complement of different wild, domestic animals and humans: host-patogen interaction.
 TICHÁ, Lucie
Sensitivity of Borrelia burgdorferi sensu lato to serum complement from various animals and humans was analyzed. Complement-mediated Borrelia killing was observed in different combination of host serum and Borrelia genospecies. The obtained results revealed species-specific patterns of viability or mortality of spirochetes that is associated with host reservoir competence for Borrelia genospecies. The results confirmed the fact that parasite-host relationship determines the competent reservoir of Borrelia genospecies in nature. The complement of the host may have a key role in the global ecology of Lyme disease.
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National Repository of Grey Literature : 12 records found   previous11 - 12  jump to record:
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