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	Myocardial beta-adrenergic signaling during adaptation of rats to chronic hypoxia Hahnová, Klára ; Novotný, Jiří (advisor) ; Ostašov, Pavel (referee) Endogenous cardiac protection against acute ischemia/reperfusion injury can by increased by cardiac adaptation to various forms of chronic hypoxia. Chronic hypoxia induces a large variety of adaptive changes in the myocardium that could be considered as protective, but the exact mechanism of increased ischemic tolerance is unknown. Different studies suggest that catecholamine release and their effect on -adrenergic signaling after adaptation to chronic hypoxia contributes to cardioprotection. In this study we focused on characterization of -adrenergic receptors ( -ARs) in the myocardium of rats after adaptation to three different hypoxic conditions: 1. intermittent normobaric hypoxia - INH/R (23 h hypoxia, 1 h reoxygenation), 2. intermittent normobaric hypoxia - INH (8 h hypoxia, 16 h normoxia), 3. continuous normobaric hypoxia - CNH (24 h hypoxia). We compared how each hypoxic model affects the total number of -adrenergic receptors and proportion of individual subtypes ( 1-and 2-ARs) in the left and right ventricles compared control normoxic rats. The INH model had apparently no effect on -ARs in either ventricles. On the other hand, adaptation to INH/R and CNH was accompanied by a significant decrease (by about 25%) in the total number of -adrenergic receptors in the right ventricles. Our present... Detailed record
	Experimentální model ischemicko-reperfúzního poškození laloku musculus latissimus dorsi prasete domácího Richtr, Patrik ; Univerzita Karlova. Detailed record
	Profily genové exprese u ischemicko reperfuzního poškození a jejich význam pro transplantaci ledviny Viklický, Ondřej ; Institut klinické a experimentální medicíny Detailed record
	Prasečí model ruptury aneurysmatu abdominální aorty. Vliv časování hyperoxie na parametry inflamace a ischemicko-reperfuzního traumatu Šrámek, Vladimír ; Fakultní nemocnice u svaté Anny (Brno, Česko) Detailed record
	Predikce rozvoje compartment syndromu po reperfuzi ischemické končetiny na základě biochemického monitoringu Mitáš, Petr ; Všeobecná fakultní nemocnice (Praha, Česko) Detailed record
	Použití miniinvazivního mimotělního oběhu (mini-CPB) při operacích srdce Lonský, Vladimír ; Manďák, Jiří ; Fakultní nemocnice (Hradec Králové, Česko) Detailed record
	Ischemicko-reperfuzní syndrom transplantované ledviny - možnosti jeho ovlivnění aplikací antioxidačních látek. Aplikovaný výzkum Kuntscher, Vilém ; Třeška, Vladislav ; Univerzita Karlova. Detailed record

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