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Molecular cytogenetic analysis of marker chromosomes and related abnormalities
Semanko, Adam ; Kočárek, Eduard (advisor) ; Holá, Dana (referee)
The primary focus of this diploma thesis is on marker chromosomes and phenotypically similar human karyotype polymorphisms, variants of short acrocentric arms in particular. The first half provides a very useful review of literature concerning different aspects of both sSMC and human polymorphisms such as their origin, inheritance, associated phenotype, formation and molecular cytogenetic methods that are applied in the process of identification of these aberrations. The methodical emphasis is on FISH and its modifications (e.g. M-FISH, acro M FISH, cen M-FISH) as well as on the CGH methods. The main objective was to test the above-mentioned methods and state their limitations and applications. Thus, in the other half we provide evaluations of commonly used methods and introduce new strategies that could be implemented to make the identification of these additional chromosomes or satellite translocations more effective. All the conclusions are based on the analysis of 7 patients with sSMC and 4 patients with variants involving acrocentric NOR regions. The results of our thorough research into their karyotypes have been compared with similar findings in the literature. Last but not least, we tried to establish a link between observed abnormalities and the type of a chromosomal aberration at hand.
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Mosaic techniques and their use for a second grade of primary school
ČÍŽKOVÁ, Barbora
The main topic for this theoretic-practical thesis is mosaic and its techniques. The main goal in the theoretical part of the thesis is to introduce the readers with this technique and its issues. The thesis deals with mosaic in general, from understanding the definitions which are necessary to clarify the issue, over the techniques, history, but also suggestions and the overall evolution of this craft/art/creation. The history of mosaic occupies the largest part of the thesis. Neglected is neither the Czech mosaic and its development. The whole one chapter is dedicated to this theme. A part of the theoretical chapter is a brief summary of the use of mosaics at schools. The practical part of the thesis will be dedicated to authorial creation and a sample lesson using mosaic at elementary school.
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Crocks of Safari -mosaic images, a diptych
DOULÍKOVÁ, Radka
My graduation thesis is called {\clq}qCrocks of Safari`` and it is divided into two main segments. The First part is theoretical which explains my inspiration, choice of theme and material, method of working - starting with design, ending with final artwork and its installation. It also considers the techniques of mosaic creation. It includes image documentation, which enriches and completes the text. The Second part is practical which includes its own graphic creation. That is two mosaic images made out of combined material {--} ceramics and glass (mirror) inserted into a metal frame. It features graphic structures and elements of an African fauna. It specifically interprets cut outs from herd of zebras and their typical stripes. My goal was to create abstract images where you can feel the character of used material and harmony of natural structures.
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