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Growth and bone mineral density in girls with Turner syndrome
Matysková, Jana ; Zemková, Daniela (advisor) ; Koloušková, Stanislava (referee)
Turner syndrome is disease caused by monosomy or other abnormalities of chromosome X. This syndrome affects exclusively females and is characterized by growth retardation leading to short final stature, gonadal dysgenesis and other abnormalities of different organs. This work describes current etiological and diagnostic aspects of Turner syndrome, especially growth failure and low bone mineral density as a factor contributing to increased bone fragility.
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Acipimox during Short-Term Exercise Exerts A Negative Feedback of Growth Hormone on Ghrelin Secretion in Patients with Bulimia Nervosa and in Healthy Women: The Role of Lipolysis
Smitka, Kvido ; Nedvídková, Jara (advisor) ; Kršek, Michal (referee) ; Čáp, Jan (referee)
Title: Acipimox during Short-Term Exercise Exerts A Negative Feedback of Growth Hormone on Ghrelin Secretion in Patients with Bulimia Nervosa and in Healthy Women: The Role of Lipolysis Objective: Eating disorders, such as bulimia nervosa (BN) and anorexia nervosa (AN), are characterized by abnormal eating behavior. The main features of BN are binge-eating and inappropriate compensatory methods to prevent weight gain. The appetite-modulating peptide ghrelin is secreted by the stomach and shows a strong release of growth hormone (GH). A potential GH-ghrelin feedback loop between stomach and the pituitary has been recently reported. Acipimox (Aci), an analogue of nicotinic acid, inhibits lipolysis in adipose tissue (AT) and reduces plasma glycerol and free fatty acids (FFA) levels. Exercise and Aci are stimulators of GH secretion. We suppose that a negative feedback from increased GH levels during exercise may play a role in reducing plasma ghrelin levels. We surmised that altered baseline activity and exercise-induced activation of the sympathetic nervous system (SNS) results in excessive stimulation of lipolysis associated with negative energy balance and may lead to abnormal AT metabolism in patients with BN. Disruption of the gut-brain-AT axis might be involved in the pathogenesis of BN. The...
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The analyse of polymorphisms of chicken
TYLLEROVÁ, Helena
Chicken growth hormone gene was examined in chosen strains from DOMINANT CZ breeding program - Rhode Island Red (RIR), New Hampshire (NH) and the final hybrids RIRxNH and NHxRIR. Polymerase chain reaction - restriction fragment length polymorphism (PCR-RFLP) analyses reveal three MspI restriction sites of intron 1 region. These restriction sites give rise to six RFLP fragments {--} 540 bp, 390 bp, 270 bp, 240 bp, 150 bp, 120 bp. Based on restriction patterns, three alleles of growth hormone were determined. From a possible six genotypes, only four were found in all populations. The allele A1 is the most abundant in RIR strain (0.925), allele A3 is the most abundant in NH strain (0.550). The allele A1 was present in the most of the hybrids.
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