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Determination of the compressibility of excipients used for formulation of tablets with theophylline.
Kousoulidou, Viktoria ; Šklubalová, Zdeňka (advisor) ; Ondrejček, Pavel (referee)
1 Abstract Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical Technology Consultant: Assoc. Prof. PharmDr. Zdenka Sklubalova, Ph.D. Student: Viktoria Kousoulidou Title of Thesis: Determination of the compressibility of excipients used for formulation of tablets with theophylline The current thesis is focused on the compressibility properties of five powders used in tablet formulation: Comprecel, Spherolac, DI-CAFOS D160, DI-CAFOS A150 as excipients and Theophylline as the active substance. The particle size, moisture content, bulk density and flowability of the powders are determined. The powders are compressed and the results are evaluated by means of the parameters of the compaction equation and the force-displacement method (compression under 5, 10, 15 kN). Then, the crushing strength of tablets prepared from each powder by the force-displacement method is measured. The average values of the crushing strength are used to calculate the tensile strength of the tablets. Best compressibility is found in Comprecel and Theophylline with tensile strength values of 1.31 MPa under 5 kN, 3.31 MPa under 10 kN, 4.75 MPa under 15 kN and 1.02 MPa under 5 kN, 2.27 MPa under 10 kN, 3.09 MPa under 15 kN, respectively.
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Evaluation of compressibility of tableting mixtures containing theophylline using a compaction equation
Matyášová, Andrea ; Šklubalová, Zdeňka (advisor) ; Svačinová, Petra (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department: Department of Pharmaceutical Technology Consultant: Doc. PharmDr. Zdeňka Šklubalová, Ph.D. Student: Andrea Matyášová Title of Thesis: Evaluation of compressibility of tableting mixtures containing theophylline using a compaction equation This thesis is aimed at the evaluation and comparison of excipients used in production of tablets. The compaction process of these excipients was evaluated using the parameters of the compaction equation. The mixtures of four fillers in various ratios were evaluated. These mixtures contained also theophylline as model drug and magnesium stearate as lubricant. The used three-exponential equation was previously developed by doc. RNDr. Milan Řehula, CSc. By using this compaction equation the volume reductions, speeds of volume reductions and consumed energies were calculated and evaluated. The results of this work showed that particular used fillers have different effect on the compaction process flow. That is caused primarily by different behavior of these materials during compaction and by formation of different types of bonds. Also the need of thorough cleaning and drying of compaction aid before compaction was confirmed.
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Evaluation of tensile strength of tablets containing theophylline
Janoutová, Hana ; Šklubalová, Zdeňka (advisor) ; Ondrejček, Pavel (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Consultant: Doc. PharmDr. Zdeňka Šklubalová, Ph.D. Student: Hana Janoutová Title of Thesis: Evaluation of tensile strength of tablets containing theophylline The aim of this thesis was to determine tensile strength of tablets containing theophylline. Tensile strength was studied as a function of the composition of mixtures of the used fillers and especially on their ratio. In the theoretical part, the used materials - lactose SpheroLac 100, microcrystalline cellulose Comprecel 102, dibasic calcium phosphate dihydrate Di-Cafos D160, anhydrous dibasic calcium phosphate Di-Cafos A150, theophylline and magnesium stearate are described. This work also evaluates force-displacement record, tensile strength and various factors that affect tensile strength. Parameters of force-displacement record and tensile strength of the tablets compressed with compresssion force 10 kN were evaluated in the experimental part. The measured results show that higher values of precompression energy (E1) and energy of plastic deformation (E2) were detected in mixtures A, C and E which contain Comprecel 102, and the lowest values were detected in mixtures B which contain Sphero-Lac 100 and Di-Cafos D160. Values of energy...
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Evaluation of disintegration time of tablets containing theophylline
Brtnová, Soňa ; Šklubalová, Zdeňka (advisor) ; Mužíková, Jitka (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical Technology Thesis supervisor: Doc. PharmDr. Zdeňka Šklubalová, Ph.D. Consultant: Mgr. Pavel Ondrejček Student: Soňa Brtnová Title of Thesis: Evaluation of disintegration time of tablets containing theophylline The influence of used fillers on energetic profile of compression, especially influence on disintegration time of tablets with theophylline as a model drug, was studied in this thesis. Four tablet fillers were studied - microcrystalline cellulose Comprecel 102, lactose SpheroLac 100, calcium hydrogen phosphate anhydrous Di- Cafos A150 and calcium hydrogen phosphate dihydrate Di-Cafos D160. Tablets contained different proportion of two fillers, theophylline as a model drug and lubricant magnesium stearate. Tablets were compressed by the same compaction force 10 kN. The force- displacement record was evaluated using the particular energies of compaction process. Parameters of compaction process were influenced mostly by Comprecel 102. According to results there is no possibility to replace Di-Cafos D160 with Di-Cafos A150 in the mixtures. It was also found that SpheroLac 100 and Di-Cafos D160 shows similar behavior. Time of disintegration of tablets is mostly dependent on the used fillers. Tablets...
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Suggest and compare possibilities of manipulation and treatment of long -term stored straw briquettes.
DEMETER, Jan
The main content of this bachelor´s work in the study discipline called Means of Transport and Manipulation is suggesting and comparing technological links for production, manipulation and storage of straw briquettes on the basis of a literary research. Technological links for a seasonal and a year-round production of the briquettes are mentioned there as well. The main goal is to construct a model link for production and storage of straw briquettes.
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