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Influence of Botulinum Toxin Application on Quality of Life in Patients with Multiple Sclerosis
Miňová, Zuzana ; Jirásková, Lucie (advisor) ; Kövári, Martina (referee)
The aim of the bachelor's thesis is to find out how medical application of botulinum toxin can affect the quality of life in patients with multiple sclerosis. The thesis is based on theoretical research providing a brief overview of the basic facts about multiple sclerosis - its pathogenesis, etiology, clinical picture, treatment alternatives. Further on, the thesis deals with the concept of spasticity, possibilities to influence it and also its valuation. The subsequent section comprises an overview of the findings about botulinum toxin and its therapeutic application. The term quality of life, an influence of the disease on the quality of life and also the methods used to evaluate it are described at the end of the theoretical part. The practical section contains case histories of two patients who underwent the medical application of botulinum toxin. The thesis is closed by a discussion on this topic. Powered by TCPDF (www.tcpdf.org)
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Therapy of spasticity with botulinum toxin and assessment of the effect by Tardieu Scale
Hochová, Anna ; Angerová, Yvona (advisor) ; Svěcená, Kateřina (referee)
Title: Therapy of spasticity with botulinum toxin and assessment of the effect by Tardieu Scale Abstract: This paper discusses paralysing effect of botulinum toxin which is used to treat spastic muscles in contemporary medicine. The paper focuses on spasticity in patients with disorder of the central nervous system caused most commonly by stroke. At first it deals with theoretical knowledge about physiology of movement, then describes active ingredient and explains the mechanism of its effect. It dedicates a lot of attention to follow-up rehabilitation as an integral part in the management of spasticity. This paper is based on two case histories. A practical part describes in detail patient's condition before and after application of botulinum toxin. A progress of the effect was assessed during periodic meetings. These instruments were used to assess: Tardieu Scale of spasticity and Frenchay arm test. In connection with the application of botulinum toxin is emphasized active co-operation of the patient. It is an essential precondition for positive results in the management of spasticity. Key words: spasticity Tardieu Scale upper motor neuron syndrome Frenchay arm test botulinum toxin kinesiotherapy occupational therapy
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Possibilities of physiotherapy in patients with cerebral palsy in the treatment of spasticity in the ankle
Petrů, Dita ; Molnár, Petr (advisor) ; Hamarová, Zuzana (referee)
This thesis deals with the extensive subject cerebral palsy in children, focusing on spasticity in the ankle joint, and the possibilities of influencing it in a conservative and operative manner. The thesis further deals with the choice of methods and physiotherapy means with regard to the type of disease and the patient's cooperation. The picture of the disease differs for each patient, thus also the type of rehabilitation, the procedure and use of therapy. One limitation to achieving optimum results with this disease is often mental retardation of varying degrees, which prevents the patient not only from understanding the implementation of the therapy, but also the motivation for implementing it. It is therefore necessary to proceed individually, with patience and sufficient time given to the care for the patient.
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Effect of botulinum toxin use in muscle spasticity
Tintěrová, Alena ; Kraus, Josef (advisor) ; Smékal, David (referee)
This study has brought an overview of botulinum toxin and its influence on the human muscles, especially on spastic muscles. In the practical part is resumed experience with botulinum toxin A therapy in children with cerebral palsy. There were observed two groups. Group A (n=9) was measured before and after therapy. Patients in group B (n=24) filled out a table of the global spasticity scale, which they returned by mail. All the patients improved after the treatment. Powered by TCPDF (www.tcpdf.org)
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Botulotoxin: dangerous poison or useful remedy?
HAMERNÍKOVÁ, Magdalena
ABSTRACT Botulotoxin: dangerous poison or useful remedy? Regarding present awareness of biological agents and the possibilities for terrorist groups several possible sources, which are most likely to be abused in biological weapons and subsequent spread of these diseases (sources) in population have been addressed, botulotoxin is one of them. Poisoning with botulotoxin (botulism) is a possible variant of bio-terrorist attack, which is considered real at present.. Botulotoxin is used in cosmetics, particularly for smoothening wrinkles, and is also applied in medicine. The aim of my thesis was to gather summarized information on botulotoxin and the possibilities of its abuse as poison for terrorist attack, to enlighten its availability, the way of use by terrorist, a scenario of such an attack, the clinical progress of poisoning, possible mortalities and preventive measures minimizing them, the issues of using botulotoxin as medicine in present health care and evaluation the possible consequent risks, and evaluation of awareness of botulotoxin and bio-terrorism in general among general public and professionals. H1: Professionals consider botulotoxin one of the poisons most likely to be used as an instrument of bio-terrorism and has been high attention paid to its study. H2: General public more perceive botulotoxin as cosmetic preparation for smoothening wrinkles in a face and it has only a few informations of its terrorist abuse. Verification of the first hypothesis was performed at theoretical level by studying professional literature its critical assessment and consultation with experts. All available publications on botulotoxin and its relation to bio-terrorism of the last ten years were collected, and the reasons why botulotoxin is considered to be a suitable instrument of bio-terrorism as well as a suitable instrument in medicine and cosmetics. Verification of the second hypothesis was performed by investigation in the form of a questionnaire research. A questionnaire enabling to find out awareness of botulotoxin and bio-terrorism in general among the public was compiled. The research was conducted among the general public and among professionals, represented by members of the Integrated Rescue System in České Budějovice. The questionnaire consists of 18 questions. The samples of both the groups include 100 respondents, stratified selection of whom was performed upon consultation with an expert. Questionnaire evaluation was performed in 2 spheres. The first sphere deals with identification data and the second with general awareness. The aim of this work was to find out what the awareness of botulotoxin and bio-terrorism in general the general public and professionals was like. Finally I analysed the research results and the formulated hypotheses The research results have confirmed my hypotheses. They show that the examined general public sample and the sample of professionals could not have been chosen from an identical outside group, the difference between them is statistically significant. Professionals are statistically significantly better aware of botulotoxin features than the general public. This thesis represent an information source for those interested in these issues, particularly for the Integrated Rescue System units.
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