National Repository of Grey Literature 2 records found  Search took 0.01 seconds. 
Relationships between Metabolism of Homocysteine and Physiological Formation of Thiodiglycolic Acid
Přistoupilová, K. ; Přistoupil, T. I. ; Šenholdová-Dlasková, Z. ; Navrátil, Tomáš
Thiodiglycolic acid (TDGA), structurally S(CH2COOH)2, is a part of the metabolic pathway used by the human organism to remove dicarbon units produced in catabolic processes TDGA origanates from glycolate and glutathione (GSH). The latter is dependent on the release of cysteine from homocysteine under the influence of vitamins folate and B12.
Thiodiglycolic Acid in Urine
Navrátil, Tomáš ; Šenholdová-Dlasková, Z. ; Heyrovský, Michael ; Přistoupilová, K. ; Přistoupil, T. I.
Thiodiglycolic acid (TDGA) is a physiological intermediate of the metabolism of cysteine which originates from homocysteine transformation. Estimation of increased levels of TDGA in urine reveals indicates intoxication of workers in chemical industry by halogenated organic solvents. Therefore our cheap and simple analytical method of TDGA determination is a contribution to toxicological control in industry.

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