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Supercritical Impregnation of Natural Extracts in Polymer.
Komárková, Anežka
The vision of this work is to prepare polymeric support loaded with natural extracts and their bioactive compounds in order to create\nwound dressing with anti-inflammatory and anti-bacterial properties. The use of such a dressing may contribute to the wound’s healing\nmechanism by creating a proper physiologic environment, being a barrier for microorganisms and releasing bioactive compounds to the\nwound site.
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Synthesis and Cytotoxicity of Fluorinated Amino Saccharides.
Hamala, Vojtěch
This work presents the synthesis of acetyl, propionyl, and butyrylesters of monofluorinated, difluorinated, and trifluorinated analogues\nof N-acetyl-d-glucosamine and N-acetyl-d-galactosamine, and theircytotoxicity expressed as IC50 values against the MDA-MB-231 cancer\ncell line (triple-negative breast cancer) along with their IC50 valuesagainst the HEK-293 non-cancerous cell line.
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Deoxyfluorinated N-acetyllactosamines as Tailored Carbohydrate-based Probes for Human Galectins.
Kurfiřt, Martin
this work, I prepared a complete series of mono‑deoxyfluorinated N-acetyllactosamine analogues 1-6. The synthesis of each analogue\nrequired approximately 15 synthetic steps, including deoxyfluorination of monosaccharide precursors, chemical glycosylation and\ndeprotection. Their binding affinities to the two most explored human galectin-1 and -3 were determined by ELISA and 19F NMR T2-filter\ntechniques, which enabled the identification of hydroxyl groups, crucial in the non-covalent recognition by galectins. This binding study\nalso permitted to compare both tested galectins in terms of their substrate specificity, revealing subtle differences, which could be utilized\nin the development of selective galectin inhibitors. Furthermore, the series is also a perfect tool to study the molecular origin of recognition\nevents via epitope-mapping 19F NMR techniques.
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Modular Synthesis of Dendritic Amphiphiles.
Edr, Antonín
The synthesis of such structures starts by an attachment of alkyl chain/s R and dendritic wedge/s to the starting molecules. These dendritic wedges are ended by three allyl groups so that various polar groups can be conjugated to the periphery of the wedge by so called thiol-ene click reaction. In addition to the resulting symmetrical structures, a synthesis of their unsymmetrical analogues bearing fluorescent tag on one of its arms (Figure 1) will be presented.
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Solvent Assisted 2D Mesoporous g-C3N4 Modification for Catalytic Application.
Dolai, Susmita
Here we show a facile and scalable new approach for the synthesis of ordered CN materials with an excellent photoactivity, which consists\nof supramolecular interfacial preorganization of monomers at the interface of two non-miscible solvents. Molecular dynamic simulations\nsupported by experimental results reveal that appropriate mono-mers and solvents choice lead to the formation of a supramolecular assembly solely at the interface of the solvents. As a proof of concept, we show the chemical and physical properties of the g-C3N4 materials after thermal condensation in various temperature. The advantages of the new method are demonstrated here through the tuneable morphologies and surface area, the formation of new electronic junctions and high activity as a photocatalyst for hydrogen evolution and pollutants degradation of the g-C3N4 materials.
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Application of Hydrodynamic Cavitation in Brewing.
Štěrba, Jiří
We have applied such advantages in the brewery industry. Venturi jet system is chosen as the HC technique due to energy saving and\nrobust design. In the field of beer brewing, we would like to investigate several phenomena, such as the isomerization of bitter hop acids,\nthe reduction of gluten concentration or the cell walls breakdown. All these experiments will be performed on the already constructed experimental brewery system.
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Multiphase Flow of Taylor Bubbles in Rectangular Microchannels.
Regner, Dominik
The aim of this work is to broaden our knowledge of the behavior of Taylor bubbles in a coflowing liquid inside flat microchannels with a high aspect ratio. The primary focus is put on the near-wall region, which is difficult to study both experimentally or numerically. The investigated quantities are the thickness of a liquid film separating the bubble from the microchannel wall, wall shear stress induced by the bubble movement, and the shape and velocity of the translating bubble.
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Three Dimensional CFD Model of a Single Rising Bubble in Stagnant Liquids.
Crha, Jakub
Two-phase (gas-liquid) flows are fundamental to wide range of chemical industrial processes such as absorption or distillation. Gaseous\nphase is mostly represented by rising bubble swarms through the liquid bulk. Physicochemical properties of the liquid and gaseous phases\ntogether with the bubble diameter and shape largely affect the bubble rise velocity, which defines the residence time of the bubble in the liquidbulk.1. Bubble behaviour can be studied experimentally, theoretically or most recently - using CFD solvers. These solvers are designed\nto numerically solve Navier-Stokes equations.
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