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Interactions between Hyaluronan and Surface Active Substances
Krouská, Jitka ; Burgert,, Ladislav (oponent) ; Lehocký,, Marián (oponent) ; Vikegard,, Peter (oponent) ; Pekař, Miloslav (vedoucí práce)
Influence of hyaluronan on surfactant micellization was studied by different physico-chemical methods. For this purpose, two cationic surfactants were chosen: tetradecyltrimethylammonium bromide (TTAB) and cetyltrimethylammonium bromide (CTAB). Isothermal titration calorimetry was used to determine enthalpy of micelle (aggregate) formation and tensiometry was useful for the description of the surface properties of the prepared samples. The different molecular weight of hyaluronan and the different alkyl chain length of the surfactant are taken into account. The results are evaluated to obtain the values of critical micelle or aggregation concentration of surfactants and the question of possible application of these systems as drug delivery systems is also discussed.
Interactions between Hyaluronan and Surface Active Substances
Krouská, Jitka ; Burgert,, Ladislav (oponent) ; Lehocký,, Marián (oponent) ; Vikegard,, Peter (oponent) ; Pekař, Miloslav (vedoucí práce)
Influence of hyaluronan on surfactant micellization was studied by different physico-chemical methods. For this purpose, two cationic surfactants were chosen: tetradecyltrimethylammonium bromide (TTAB) and cetyltrimethylammonium bromide (CTAB). Isothermal titration calorimetry was used to determine enthalpy of micelle (aggregate) formation and tensiometry was useful for the description of the surface properties of the prepared samples. The different molecular weight of hyaluronan and the different alkyl chain length of the surfactant are taken into account. The results are evaluated to obtain the values of critical micelle or aggregation concentration of surfactants and the question of possible application of these systems as drug delivery systems is also discussed.

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