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Národní úložiště šedé literatury Nalezeno 3 záznamů.  Hledání trvalo 0.00 vteřin. 
Functional analysis of tick salivary serine and cysteine protease inhibitors
 KOTÁL, Jan
The proposed thesis focuses on the characterization of two protease inhibitors present in tick saliva. More specifically, the thesis presents immunomodulatory properties, biochemical specificity and structure of a cysteine protease inhibitor named Iristatin. Another characterized protein, IRS-8, comes from a serpin family (serine protease inhibitors) and inhibits blood coagulation and complement system in the host. Furthermore, the thesis provides a literature overview and discussion of tick salivary molecules in the context of tick-host-pathogen interaction, vaccination potential and medicine potential. Two review manuscripts, which are part of this thesis summarize the effects of tick saliva and protease inhibitors on host immune mechanisms.
Úplný záznam
Production and functional characterization of tick salivary protease inhibitors
 KOTÁL, Jan
Two cysteine and two serine protease inhibitors from a tick Ixodes ricinus saliva were overexpressed using a prokaryotic overexpression system and refolded to their native state. Both cysteine protease inhibitors were tested as potential antigens for an anti-tick vaccine showing no effect on tick feeding or reproduction. Various immunological methods were employed to test the potential immunomodulatory function of these proteins without success.
Úplný záznam
Towards the functional characterization of a "cysteine rich" protein family member from \kur{Ixodes ricinus}
 KOTÁL, Jan
The function of a cysteine rich family member from the tick Ixodes ricinus was investigated using RNA interference and serine protease inhibition assays of the recombinant polypeptide. Both methodologies suggest that this protein most likely does not influence tick?s feeding ability.
Úplný záznam

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