|
|
Probing natural molecules with PPAR- to reveal potent agonist against Cancer
Špaková, Adriána ; Bhogal, Inderjeet (oponent) ; Roy, Sudeep (vedoucí práce)
The work focuses on searching for a natural molecule with potential agonistic properties against cancer. The aim of the work was primarily to understand the connection between the peroxisome proliferator-activated receptor gamma (PPAR-) and cancer. Subsequently, molecules from six databases were virtually screened and docked to nuclear receptor PPAR- by using computer aided drug design approach. Hits underwent further exploration, including a dynamic simulation and binding free energy study. Safety verification of the best molecules was performed by ADMET prediction models. An important part of the work was the comparison of newly discovered molecules possessing agonistic properties against cancer with those already known on the market. Specifically, Troglitazone and Rosiglitazone have served as standards, characterized by their high affinity to the PPAR- receptor and demonstrated antineoplastic effects in various human malignant tumors, including breast, colorectal, and pancreatic cancer. On the other hand, these two synthetic molecules face a warning from the FDA (Food and Drug Administration) due to their adverse side effects. Within the study, natural molecules with better properties than the current standards have been discovered. These promising results deserve further attention. One of these molecules could potentially lead to the development of a new drug.
|
|
|
Synchronization and practical use of isokinetic dynamometer with surface electromyography unit
Špaková, Adriána ; Hanák, Petr (oponent) ; Šťastný, Jan (vedoucí práce)
The bachelor's thesis deals with a design proposal for the solution of synchronization of an isokinetic dynamometer with a surface electromyography unit, and subsequently performs the realization of their synchronization. These devices are used as diagnostic and therapeutic medical technique and in practice are standardly used separately. It is expected that by using them simultaneously would be possible to obtain more detailed information about the condition of the examined individual. Synchronized devices can thus be useful, for example, for the analysis of muscle performance of patients with neuromuscular diseases or athletes who want to improve their quality of life after suffering an injury or plan comeback to their favourite activity. After successful synchronization, the work is focused on testing the muscle activity of flexors and extensors of the knee joint of athletes. Measurements were performed on healthy subjects as well as those who had suffered knee injuries in the past. The measured signals were processed, and the measurement results were interpreted. The work includes the elaboration of all the goals based on its assignment, including the main idea of the work, what is the successful synchronization of the isokinetic dynamometer with the surface electromyography unit and their practical use.
|
|
|
Synchronization and practical use of isokinetic dynamometer with surface electromyography unit
Špaková, Adriána ; Hanák, Petr (oponent) ; Šťastný, Jan (vedoucí práce)
The bachelor's thesis deals with a design proposal for the solution of synchronization of an isokinetic dynamometer with a surface electromyography unit, and subsequently performs the realization of their synchronization. These devices are used as diagnostic and therapeutic medical technique and in practice are standardly used separately. It is expected that by using them simultaneously would be possible to obtain more detailed information about the condition of the examined individual. Synchronized devices can thus be useful, for example, for the analysis of muscle performance of patients with neuromuscular diseases or athletes who want to improve their quality of life after suffering an injury or plan comeback to their favourite activity. After successful synchronization, the work is focused on testing the muscle activity of flexors and extensors of the knee joint of athletes. Measurements were performed on healthy subjects as well as those who had suffered knee injuries in the past. The measured signals were processed, and the measurement results were interpreted. The work includes the elaboration of all the goals based on its assignment, including the main idea of the work, what is the successful synchronization of the isokinetic dynamometer with the surface electromyography unit and their practical use.
|
host ::
RSS.