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Differentiation potential of human dental pulp mesenchymal stem cells
Vacková, Kristýna ; Voltrová, Barbora (advisor) ; Steklíková, Klára (referee)
Nowadays, dental pulp mesenchymal stem cells (dpMSC) are very popular amongst stem cells used for the study of cell therapy and regenerative medicine, due to their broad differentiation potential and simplicity of isolation. They are isolated from third molars which are often removed during routine surgeries in dentistry and would otherwise be discarded without any benefit as a waste material. Moreover, there are no ethical problems connected with their use. DpMSC fulfil all criteria established for mesenchymal stem cells, proliferate sufficiently and have a long lifespan in vitro. Besides their ability to differentiate into osteogenic, adipogenic and chondrogenic lineage, dpMSC are capable to differentiate into neurogenic, myogenic and hepatogenic lineage and into melanocytes and endothelial cells. Especially, dpMSC are used on animal model organisms for in vivo regeneration of tooth, bone, muscle, neuronal and liver tissue. Currently, several clinical trials are investigating the regenerative potential of dpMSC in humans. Apart from application in stomatology for tooth or bone regeneration, they can also be used for the treatment of the neurogenic diseases and for many other applications, on account of their origin in neural crest. The aim of this work was to write a literature review focused on...
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