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National Repository of Grey Literature 2 records found  Search took 0.01 seconds. 
Pyrazine derivatives as potential antimycobacterial drugs I.
 Vobicková, Jana ; Doležal, Martin (advisor) ; Kopecký, Kamil (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Drug Control Candidate: Jana Vobicková Supervisor: Prof. PharmDr. Martin Doležal, Ph.D. Title: Pyrazine derivatives as potential antimycobacterial drugs I. In this diploma thesis basic information on tuberculosis, its treatment and trends in the devolopment of new drugs were presented. There were synthetised seven esters of the 3-aminopyrazin-2-carboxylic acid. The CEM Discover microwave reactor with autosampler Explorer 24 which served to accelerate the reaction was used for synthesis. The series of prepared products was characterized by IR, 1 H NMR, 13 C NMR spectra and melting points. Log P and Clog P were calculated. Products were put through in vitro antimycobacterial activity.
Detailed record
Pyrazine derivatives as potential antimycobacterial drugs I.
 Vobicková, Jana ; Doležal, Martin (advisor) ; Kopecký, Kamil (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Drug Control Candidate: Jana Vobicková Supervisor: Prof. PharmDr. Martin Doležal, Ph.D. Title: Pyrazine derivatives as potential antimycobacterial drugs I. In this diploma thesis basic information on tuberculosis, its treatment and trends in the devolopment of new drugs were presented. There were synthetised seven esters of the 3-aminopyrazin-2-carboxylic acid. The CEM Discover microwave reactor with autosampler Explorer 24 which served to accelerate the reaction was used for synthesis. The series of prepared products was characterized by IR, 1 H NMR, 13 C NMR spectra and melting points. Log P and Clog P were calculated. Products were put through in vitro antimycobacterial activity.
Detailed record

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