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Diseases in populations from the Roman period in terms of paleopathology.
Hlavenková, Lucia ; Smrčka, Václav (advisor) ; Vargová, Lenka (referee) ; Komoróczy, Balázs (referee)
Human osteological and dental remains are important for reconstruction of health and disease patterns in the past, preserving information in the form of abnormal changes on bones and teeth. These changes can reflect the spread of numerous diseases and the consequences they had on the health of various historical populations and groups. Systematic investigation performed within the present thesis explored pathologies in skeletal collections from six archaeological sites from across Slovakia and Hungary, dating to the 1st and 5th centuries AP. The total sample consisted of 300 individuals that were divided among three populations: the Germanic (GS), the Roman (RS) and the Sarmatian series (SS). Pathologies were assessed macroscopically and discussed on population and individual levels. Overall, sex, age and lesion distribution frequencies were used to determine a disease pattern characteristic for a corresponding group and then compared between the series. Conditions identified during the analysis were arranged into nine main categories. The analysis revealed that the health status of GS, RS and SS was generally good, though adults from GS and RS had experienced poorer dental health. The most common lesions observed in all series, particularly in GS, were due to degenerative and dental diseases,...
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Immunointerventional therapy of autoimmune diabetes with recent oncet in NOD mice.
Vargová, Lenka ; Saudek, František (advisor) ; Štechová, Kateřina (referee) ; Mráz, Miloš (referee)
Introduction: Type 1 diabetes mellitus is a chronic metabolic disease caused by autoimmune destruction of pancreatic beta cells. The theory of the disease onset is derived from study of a disease course in non-obese diabetic (NOD) mice, in which the diabetes occurs due to a dysregulation of the immune system. Experimental and clinical studies showed that the autoimmunity may be abrogated by immune intervention, which if initiated early enough may at least slow down the ongoing beta cells lost and preserve residual insulin secretion. But immune intervention alone is not sufficient to restore normoglycemia in the majority of cases. Several interventional studies showed that stimulation of proliferation and/or regeneration of beta cells are necessary to restore normoglycemia in animal models. Aim of the study: To find out, if the combination of a potent immunosuppression (murine anti-thymocyte globulin (mATG), gusperimus) together with stimulation of islet regeneration (sitagliptin) will be able to slow down or reverse the course of the disease. Another aim is to identify the mechanism by which the substances act. Material and methods: All experiments were performed in female NODShiLtJ (H2g7 ) mice. The following parameters were examined at day 0, 7, 14 and 28: blood glucose, subpopulations of...
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Diseases in populations from the Roman period in terms of paleopathology.
Hlavenková, Lucia ; Smrčka, Václav (advisor) ; Vargová, Lenka (referee) ; Komoróczy, Balázs (referee)
Human osteological and dental remains are important for reconstruction of health and disease patterns in the past, preserving information in the form of abnormal changes on bones and teeth. These changes can reflect the spread of numerous diseases and the consequences they had on the health of various historical populations and groups. Systematic investigation performed within the present thesis explored pathologies in skeletal collections from six archaeological sites from across Slovakia and Hungary, dating to the 1st and 5th centuries AP. The total sample consisted of 300 individuals that were divided among three populations: the Germanic (GS), the Roman (RS) and the Sarmatian series (SS). Pathologies were assessed macroscopically and discussed on population and individual levels. Overall, sex, age and lesion distribution frequencies were used to determine a disease pattern characteristic for a corresponding group and then compared between the series. Conditions identified during the analysis were arranged into nine main categories. The analysis revealed that the health status of GS, RS and SS was generally good, though adults from GS and RS had experienced poorer dental health. The most common lesions observed in all series, particularly in GS, were due to degenerative and dental diseases,...
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Immunointerventional therapy of autoimmune diabetes with recent oncet in NOD mice.
Vargová, Lenka ; Saudek, František (advisor) ; Štechová, Kateřina (referee) ; Mráz, Miloš (referee)
Introduction: Type 1 diabetes mellitus is a chronic metabolic disease caused by autoimmune destruction of pancreatic beta cells. The theory of the disease onset is derived from study of a disease course in non-obese diabetic (NOD) mice, in which the diabetes occurs due to a dysregulation of the immune system. Experimental and clinical studies showed that the autoimmunity may be abrogated by immune intervention, which if initiated early enough may at least slow down the ongoing beta cells lost and preserve residual insulin secretion. But immune intervention alone is not sufficient to restore normoglycemia in the majority of cases. Several interventional studies showed that stimulation of proliferation and/or regeneration of beta cells are necessary to restore normoglycemia in animal models. Aim of the study: To find out, if the combination of a potent immunosuppression (murine anti-thymocyte globulin (mATG), gusperimus) together with stimulation of islet regeneration (sitagliptin) will be able to slow down or reverse the course of the disease. Another aim is to identify the mechanism by which the substances act. Material and methods: All experiments were performed in female NODShiLtJ (H2g7 ) mice. The following parameters were examined at day 0, 7, 14 and 28: blood glucose, subpopulations of...
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