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Adhesive properties of branched polyesters plasticized with triacetin
Valuchová, Jana ; Šnejdrová, Eva (advisor) ; Mužíková, Jitka (referee)
University: Charles University of Prague Faculty: Faculty of Pharmacy in Hradec Králové Department: Pharmaceutical Technology Academic year: 2011/2012 Author: Jana Valuchová Study program: Pharmacy Supervisor: PharmDr. Eva Šnejdrová Ph.D. Title of diploma thesis: Adhesive properties of branched polyesters plasticized with triacetin. The aim of this master thesis is the study of adhesive properties of the polyesters of glycolic acid and lactic acid, branched with tripentaerythritol and plasticized with triacetin of various concentrations. The theoretical part deals with the bioadhesion, bioadhesive polymers, testing of bioadhesion, and plasticizers. The practical part is focused on the study of adhesiveness, measured as maximal force needed for the detachment of the polymer from the model substrate. The influence of model substrate, type of polyester, plasticizer concentration and incorporation of the drug on adhesiveness was studied. It was found, than 20 % of triacetin is sufficient for decreasing the viscosity of the polyesters. Even the lower concentration could be used in the further studies. The cork base can serve as model substrate for screening of the adhesivity. Adhesiveness of the tested polyesters was higher in comparison with methylcellulose, carbomer, polycarbophil and gelatine gels....
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