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The study of the properties of tablets made from the mixtures of directly compressible starch and lactitol.
Vajglová, Jana ; Mužíková, Jitka (advisor) ; Šnejdrová, Eva (referee)
The work studied the mechanical strenght and the disintegration time of tablets prepared by direct compession of mixtures of pregelatinized starch Starch 1500 and directly compresible lactitol LactyTab in proportion 1:1 and 3:1 according to the compression force (12, 16, 20kN), concentration of the lubricant, sodium stearyl fumarate, Pruv, (0, 0,5 and 1%) and addition of model active substance, acetylsalicylic acid (50%). The tablet strenght of the mixtures of Starch 1500 and lactitol in proportions 1:1 and 3:1 rose with the compression force and decreased with increasing concentration of Pruv, there was no significant difference between the strenght of the compacts with 0,5 and 1% of the lubricant for the mixture in proportion 1:1. The blend of Starch 1500 and lactitol 1:1 without any lubricant gave the firmest tablets. Similarly, the mixture in proportion 1:1 with acetylsalicylic acid showed higher strenght of the compacts which decreased with increasing concentration of Pruv. The disintegration time of the compacts rose with the compression force. The hypothesis of longer disintegration time of the tablets with bigger amount of Starch 1500 was confirmed at compression force 12 and 20kN with an exception to blends containing 1% of Pruv. The tablets including acetylsalicylic acid showed longer...
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