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Usage of antibodies and immunoconjugates in the pharmacotherapy of cancer
Vaidlová, Alena ; Čečková, Martina (advisor) ; Mladěnka, Přemysl (referee)
4 ABSTRACT Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of pharmacology and toxicology Candidate: Alena Vaidlová Supervisor: Pharm.Dr. Martina Čečková, Ph.D. Title of diploma thesis: Usage of antibodies and immunoconjugates in the pharmacotherapy of cancer. This diploma thesis display posibility of tumor treatment by antibodies, their conjugates and antibody fragments. Antibody therapy uses natural antibody binding of tumor cell or other abnormal cell. Antibodies bind only cells with cellular biomarkers which are present on target cells. Binding initiate disposal process of damaged cell. Genetic engineering helps to create different antibodies and their conjugates with different qualities, especially various affinity to specific structures they recognise. Unconjugated antibodies are chimerical, humanized, pure human or pure murine. Conjugated antibodies are represented by imunoconjugates, conjugates with cytostatics, with enzymes, with phytogenic or animal toxines. Developement of antibodies has totally new phenomenon - creating of antibody fragments. These elements are products of genetic engineering and their utilization has a great future. This work summarizes the latest knowledge about using monoclonal antibodies and immuoconjugates in theanticancer therapy.
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