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Public Spaces of the Historic City Center of Brno - SQUARES
Vaculíková, Petra ; Doc.Ing.arch.Irena Fialová (referee) ; Kroupa, Petr (referee) ; Rudiš, Viktor (referee) ; Pelčák, Petr (advisor)
Changes of physical, functional and social structure of the city as a result of the group of variously interrelated changes and events that are fundamentally participate in the formation of the image of the urban development. This doctoral thesis is based on research of the historical city center - squared. First part is focuses on the historical development of urban texture of the inner city of Brno and its squares. We are talking about Square of Freedom, Vegetable Market, Dominican square, Jacobs square, Capuchins square and Šilingrovo square. Based on individual characteristics, describing the emergence of morphological and functional changes in Brno square was created urban classification of basic types of square. City of Brno, as the capital city of region has a significant position in the structure of settlements. This fact has become one of the key aspects for the selection of examples of European cities and their squares. The second part of the thesis is based on comparative studies of different types of historical squares. In order to define the value of public spaces, it is necessary to look at the public places of historical perspective and deal with the causes that led to the decline of the importance and role of public spaces. Austrian capital cities of region (Graz, Linz, Klagenfurt and Salzburg) will be examined with regard to similar climatic conditions and a common cultural and historical context of the city. Based on urban patterns and graphic diagrams of each square are observed inner relationships between shapes of square, form, function and location of the position of an artwork. Research areas are also focused on comparing aspects of transport, green space, functional use, visual unit and social activities. The public space is shaped by a set of characteristics that promote diversity and interdependence of functions. For a better interpretation of the results have been established two benchmarks - symbol of identification with the place and the Magnet (function and filling space). The objective of the thesis is to define an aspects and elements of space which were involved in square use.
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Study of morphological and physiological aspects of Candida albicans growth in the relation to human hormones.
Vaculíková, Petra ; Buchta, Vladimír (advisor) ; Vejsová, Marcela (referee)
1. ABSTRACT Vaginal infection caused by yeasts is very frequent complication of women in fertile age.. One the most important predisposed factor are considered sexual hormones, especially estardiol. The results of clinical observations shows that this infection often occurs in women during the luteal phase of menstrual cycle, when estrogen and progesteron levels are elevated. We studied antifunal effect of sexual hormones on the growth of Candida albicans in combination with antifungal drugs. We used six clinical strains of Candida albicans from the patients with vulvovaginal candidiasis. A combination of one antifungal drug (fluconazole, amphotericin B, flucytosine) with a hormone (testosterone, progesterone, estradiol) was tested in all these strins. The results expressed as MIC of these combinations of hormone and antifungals were determined visually and spectrophotometrically. The best combination in terms of antifungal activity in vitro was amfotericin B with progesterone which showed addition. In contrast, combinations of flukonazol with all hormones were indifferent or antagonistic.
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Study of morphological and physiological aspects of Candida albicans growth in the relation to human hormones.
Vaculíková, Petra ; Buchta, Vladimír (advisor) ; Vejsová, Marcela (referee)
1. ABSTRACT Vaginal infection caused by yeasts is very frequent complication of women in fertile age.. One the most important predisposed factor are considered sexual hormones, especially estardiol. The results of clinical observations shows that this infection often occurs in women during the luteal phase of menstrual cycle, when estrogen and progesteron levels are elevated. We studied antifunal effect of sexual hormones on the growth of Candida albicans in combination with antifungal drugs. We used six clinical strains of Candida albicans from the patients with vulvovaginal candidiasis. A combination of one antifungal drug (fluconazole, amphotericin B, flucytosine) with a hormone (testosterone, progesterone, estradiol) was tested in all these strins. The results expressed as MIC of these combinations of hormone and antifungals were determined visually and spectrophotometrically. The best combination in terms of antifungal activity in vitro was amfotericin B with progesterone which showed addition. In contrast, combinations of flukonazol with all hormones were indifferent or antagonistic.
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Public Spaces of the Historic City Center of Brno - SQUARES
Vaculíková, Petra ; Doc.Ing.arch.Irena Fialová (referee) ; Kroupa, Petr (referee) ; Rudiš, Viktor (referee) ; Pelčák, Petr (advisor)
Changes of physical, functional and social structure of the city as a result of the group of variously interrelated changes and events that are fundamentally participate in the formation of the image of the urban development. This doctoral thesis is based on research of the historical city center - squared. First part is focuses on the historical development of urban texture of the inner city of Brno and its squares. We are talking about Square of Freedom, Vegetable Market, Dominican square, Jacobs square, Capuchins square and Šilingrovo square. Based on individual characteristics, describing the emergence of morphological and functional changes in Brno square was created urban classification of basic types of square. City of Brno, as the capital city of region has a significant position in the structure of settlements. This fact has become one of the key aspects for the selection of examples of European cities and their squares. The second part of the thesis is based on comparative studies of different types of historical squares. In order to define the value of public spaces, it is necessary to look at the public places of historical perspective and deal with the causes that led to the decline of the importance and role of public spaces. Austrian capital cities of region (Graz, Linz, Klagenfurt and Salzburg) will be examined with regard to similar climatic conditions and a common cultural and historical context of the city. Based on urban patterns and graphic diagrams of each square are observed inner relationships between shapes of square, form, function and location of the position of an artwork. Research areas are also focused on comparing aspects of transport, green space, functional use, visual unit and social activities. The public space is shaped by a set of characteristics that promote diversity and interdependence of functions. For a better interpretation of the results have been established two benchmarks - symbol of identification with the place and the Magnet (function and filling space). The objective of the thesis is to define an aspects and elements of space which were involved in square use.
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