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Acyclovir release from branched oligoesters
Vondráčková, Hana ; Šnejdrová, Eva (advisor) ; Dittrich, Milan (referee)
11 Summary The objective of this graduation thesis was a description of a liberation of aciclovir from plastificated oligoesters drug carriers. We used terpolymers of D,L-lactic acid, glycolic acid and dipentaerythritol or tripenaterythritol [LA/GA/D(T)]. Theoretic part is devote to processes during a liberation of a medicament from a polymer carrier also to polyesters of lactic acid, glycolic acid and their copolymers who have a remarkable impact in the field of controlled drug delivery and as well to pentaerythritol. At the experimental section we used disolution tests in order to obtain a concentration of released aciclovir by spectrophotometry. Process of liberation was diagrammatized like a dependence of cumulative precentage of released drug at a time. The results indicate that the carrier 3T is the best drug delivery vehicle for aciclovir. 3T is disposing the highest factor of branching and it has the biggest molar weight.
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Acyclovir release from branched oligoesters
Vondráčková, Hana ; Šnejdrová, Eva (advisor) ; Dittrich, Milan (referee)
11 Summary The objective of this graduation thesis was a description of a liberation of aciclovir from plastificated oligoesters drug carriers. We used terpolymers of D,L-lactic acid, glycolic acid and dipentaerythritol or tripenaterythritol [LA/GA/D(T)]. Theoretic part is devote to processes during a liberation of a medicament from a polymer carrier also to polyesters of lactic acid, glycolic acid and their copolymers who have a remarkable impact in the field of controlled drug delivery and as well to pentaerythritol. At the experimental section we used disolution tests in order to obtain a concentration of released aciclovir by spectrophotometry. Process of liberation was diagrammatized like a dependence of cumulative precentage of released drug at a time. The results indicate that the carrier 3T is the best drug delivery vehicle for aciclovir. 3T is disposing the highest factor of branching and it has the biggest molar weight.
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Influence of unisex rates on the life insurance market
Vondráčková, Hana ; Řezanková, Hana (advisor) ; Zemánek, Martin (referee)
The diploma thesis deals with possible reaction of life insurance companies to legislative decree, in which the European Union forbid, within the equality of sexes, to use sex as a factor for assessing different amount of premium between men and women. Using analysis of the product pricing of five important insurance companies helps to show, which risks (and to which extent) this change covers. Because there will be limited possibility to decide on the premium amount according to one of the most important parameters, it can be expected, this decision will have significant influence on the whole insurance market and it will indicate direction of life insurance to the future. Decision about business strategy is influenced also by other entries, such as position of the insurance company, its business network etc. As the most likely direction of market development is here considered new or more distinctive segmentation of clients, hence there are, on accessible data, using the hypothesis about the relative frequency, tested propositions of the new criteria, which could help determine more fair premium.
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