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Analysis of the Therapeutical Value of Antiepileptics
Tlustá, Eva ; Vlček, Jiří (advisor) ; Tilšer, Ivan (referee) ; Kubová, Hana (referee)
The aim of the thesis was to analyze the pharmacotherapy of epilepsy in the Czech Republic and quality of life (QOL) of patients with epilepsy as well as identification of factors with main influence on QOL. Each specific issue has been described and discussed in three chapters and published in five original papers. 1. Pharmacoepidemiology of antiepileptic drugs 1a. Pharmacoepidemiological study of a group of patients with epilepsy Aim Aim of the study was to analyze epilepsy treatment in patients from two specialized neurology departments in the Czech Republic, describe seizure type and seizure frequency, duration of the disease, antiepileptic drug (AED) treatment and employability of the patients. Methods and results Epileptic outpatients aged over 16 years with confirmed diagnosis of epilepsy attending the Centre for epileptology and epileptosurgery (CEE) Thomayer's Teaching Hospital in Prague or the Neurology department of University Hospital in Hradec Králové (FN HK) were included (n = 427). In the period April 2005 - June 2006, age, gender, type and frequency of epileptic seizures, prescribed AEDs and employability were retrieved from medical records. According to the seizure frequency, patients were classified into four groups. Seizures were classified according to the International League...
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