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National Repository of Grey Literature 3 records found  Search took 0.00 seconds. 
Muscotoxins: novel cytotoxic undecapeptides with unique structural elements and mechanism of action, isolated from soil cyanobacterium \kur{Nostoc muscorum}
 TOMEK, Petr
This project was focused on development of extraction and purification protocol for novel cytotoxic compound isolated from soil cyanobacterium Nostoc muscorum which would allow to determine its molecular structure via NMR (nuclear magnetic resonance) and MS (mass spectrometry) techniques. Purified cytotoxin was subjected to several biochemical and microscopical experiments in order to assess its toxicological parameters, determine the mechanism of action and evaluate potential application in biotechnology or pharmacy.
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Cytotoxicity and secondary metabolites production in terrestrial \kur{Nostoc} strains, originating from different climatic/geographic regions and habitats: Is their cytotoxicity environmentally dependent?
 TOMEK, Petr
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Cytotoxicity of the filamentous cyanobacteria in relation to its ecology
 TOMEK, Petr
The aims of this study was to screen a cytotoxic activity in 53 strains of the genera Nostoc and Anabaena and to compare occurence of active isolates within different ecological groups. Selected cytotoxic strains were subjected to HPLC/MS analysis to identify their extracts composition. Isolates with strong cytotoxic effect containing unknown substances were fractionated to obtain pure fraction of this compound. Finally, the selected strains toxicity dependence on time and concentration was evaluated.
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See also: similar author names
3 Tomek, Pavel
4 Tomek, Peter
4 Tomek, Prokop
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