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Endogenous markers in the etiopathogenesis of abdominal aortic aneurysms
Houdek, Karel ; Moláček, Jiří (advisor) ; Bachleda, Petr (referee) ; Šebesta, Pavel (referee) ; Staffa, Robert (referee)
Introduction Prevalence of abdominal aortic aneurysm is 2-6%. Aneurysm is on the leading possitions in death cause. Lot of patients die do to ruptured aneurysm. The etiology of abdominal aortic aneurysm remains unknown. Current treatment(resection or endovascular)is not indicated for everyone. We don't know the right conservative (pharmacological) treatment. Aims With our study, we would like to confirm the impact of atorvastatin on experimental abdominal aortic aneurysm. We would like to evaluate and quantified changes in the composition of an aneurysmatic wall under the effect of atorvastatin. Other aim is to make a summary of known knowledge of this disorder. These knowledges can help in searching for new treatment options. Methods Comparison of 2 groups of pigs with experimental abdominal aortic aneurysm. Group treated with atorvastatin and group without any pharmacological influencing. Comparing of aneurysmal growth rate. Evaluation of changes of the wall structure in both groups using a stereological tools. Review of published data. Results In our experimental work atorvastatin did not slow down the growth of the aneurysm. Effect was on the histological structure of the aneurysmatic wall. Wall structure of the aneurysm in group treated with atorvastatin was really close to wall without any...
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Allogenous venous graft in reconstructive vascular surgery - the use of immunosuppression in experiment.
Varga, Martin ; Oliverius, Martin (advisor) ; Vaněk, Ivan (referee) ; Staffa, Robert (referee)
(ENGLISH) Background: The investigation of the immunosuppression usage in cardiovascular surgery and interventional cardiology is, at present, concentrated on three main topics: 1) influence on intimal hyperplasia of coronary and peripheral vascular reconstructions 2) influence on rejection of allogeneic vascular grafts and 3) influence on intimal hyperplasia of coronary arteries after endovascular interventions. Modern immunosuppressive drug FK506 (Tacrolimus) could have a positive effect for these indications. In experimental study, FK506 inhibited rejection of arterial allografts and also inhibited intimal hyperplasia in percutaneous coronary interventions. Aims: The purpose of this study was to evaluate the effect of systemic tacrolimus treatment on the process of arterialisation of allogeneic and syngeneic venous grafts in a rat vein-to-artery implantation model. Material and Methods: Lewis (LEW) rats were used as recipients of syngeneic (Lewis) or allogeneic (Brown-Norway; BN) iliolumbar veins which were implanted into abdominal aorta. Recipients were divided into six groups. In groups A, E and F were animals after syngeneic (LEW to LEW) and in groups B, C and D were animals after allogeneic (BN to LEW) transplantations. Animals in the groups C and F had daily intramuscular injections of...
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Endogenous markers in the etiopathogenesis of abdominal aortic aneurysms
Houdek, Karel ; Moláček, Jiří (advisor) ; Bachleda, Petr (referee) ; Šebesta, Pavel (referee) ; Staffa, Robert (referee)
Introduction Prevalence of abdominal aortic aneurysm is 2-6%. Aneurysm is on the leading possitions in death cause. Lot of patients die do to ruptured aneurysm. The etiology of abdominal aortic aneurysm remains unknown. Current treatment(resection or endovascular)is not indicated for everyone. We don't know the right conservative (pharmacological) treatment. Aims With our study, we would like to confirm the impact of atorvastatin on experimental abdominal aortic aneurysm. We would like to evaluate and quantified changes in the composition of an aneurysmatic wall under the effect of atorvastatin. Other aim is to make a summary of known knowledge of this disorder. These knowledges can help in searching for new treatment options. Methods Comparison of 2 groups of pigs with experimental abdominal aortic aneurysm. Group treated with atorvastatin and group without any pharmacological influencing. Comparing of aneurysmal growth rate. Evaluation of changes of the wall structure in both groups using a stereological tools. Review of published data. Results In our experimental work atorvastatin did not slow down the growth of the aneurysm. Effect was on the histological structure of the aneurysmatic wall. Wall structure of the aneurysm in group treated with atorvastatin was really close to wall without any...
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Allogenous venous graft in reconstructive vascular surgery - the use of immunosuppression in experiment.
Varga, Martin ; Oliverius, Martin (advisor) ; Vaněk, Ivan (referee) ; Staffa, Robert (referee)
(ENGLISH) Background: The investigation of the immunosuppression usage in cardiovascular surgery and interventional cardiology is, at present, concentrated on three main topics: 1) influence on intimal hyperplasia of coronary and peripheral vascular reconstructions 2) influence on rejection of allogeneic vascular grafts and 3) influence on intimal hyperplasia of coronary arteries after endovascular interventions. Modern immunosuppressive drug FK506 (Tacrolimus) could have a positive effect for these indications. In experimental study, FK506 inhibited rejection of arterial allografts and also inhibited intimal hyperplasia in percutaneous coronary interventions. Aims: The purpose of this study was to evaluate the effect of systemic tacrolimus treatment on the process of arterialisation of allogeneic and syngeneic venous grafts in a rat vein-to-artery implantation model. Material and Methods: Lewis (LEW) rats were used as recipients of syngeneic (Lewis) or allogeneic (Brown-Norway; BN) iliolumbar veins which were implanted into abdominal aorta. Recipients were divided into six groups. In groups A, E and F were animals after syngeneic (LEW to LEW) and in groups B, C and D were animals after allogeneic (BN to LEW) transplantations. Animals in the groups C and F had daily intramuscular injections of...
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