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Vývoj umělého zubu založený na technice povrchové plasmové resonance
Solanská, Kateřina ; Solich, Petr (advisor) ; Polášek, Miroslav (referee)
For development an artificial tooth hydroxyapatite nanoparticles solution was electrophoretically deposited on the gold chip. It was established that experimental conditions of solution preparation, electrically field have marked effect to thickness of the hydroxyapatite layer. By this way was prepared chip suitable for SPR measurements. In the firs step the bovine serum albumin (BSA) was chosen as the model protein shows absorption on the hydroxyapatite layer. Further the native saliva and artificial saliva were used for pellicle forming. Samples of saliva showed difference between binding behaviors on the hydroxyapatite layer. The application of chlorhexidingluconate pharmaceuticals on the pellicle shows increase in thickness but rinsing with native saliva disclosed that the components of chlorhexidingluconate pharmaceuticals can be easily removed from the surface.
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Study of Factors Influencing Dose of Commercial Eye Drops
Solanská, Kateřina ; Šklubalová, Zdeňka (advisor) ; Mužíková, Jitka (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical technology Candidate Mgr.Solanská Kateřina Consultant Doc. PharmDr. Zdeňka Šklubalová, Ph.D. Title of Thesis Study of factors influencing dose of commercial eye drops Five commercially produced ophthalmic preparations which differed in a dispensing system and a shape of the dropper tip were used in the thesis. The influence of the surface tension, viscosity, osmolality, density, and dispensing angle on the weight of the drops produced by original dispensing system, consisting of dropper tip and dropper bottle, was examined.To evaluate the influence properties of solutions, an uniform dropper tip and uniform dropper bottle were used. The weight of the eye drops were compared with the drop weight of water and the model solutions 0.01% and 0.02% benzalkonium chloride. Direct correlation proportion was found out between the surface tension and the weight of the drops. When the dispensing angle decreased from 90ř to 45řthe weight of the drops significantly decreased too. When the dropper tip was wetted the effective circuit of the dropper tip produced larger drops increasing variability of drop weigth together with the amout of applied drugs. Out of dropper systems tested, we can conclude that the lowest...
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Study of Factors Influencing Dose of Commercial Eye Drops
Solanská, Kateřina ; Šklubalová, Zdeňka (advisor) ; Mužíková, Jitka (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical technology Candidate Mgr.Solanská Kateřina Consultant Doc. PharmDr. Zdeňka Šklubalová, Ph.D. Title of Thesis Study of factors influencing dose of commercial eye drops Five commercially produced ophthalmic preparations which differed in a dispensing system and a shape of the dropper tip were used in the thesis. The influence of the surface tension, viscosity, osmolality, density, and dispensing angle on the weight of the drops produced by original dispensing system, consisting of dropper tip and dropper bottle, was examined.To evaluate the influence properties of solutions, an uniform dropper tip and uniform dropper bottle were used. The weight of the eye drops were compared with the drop weight of water and the model solutions 0.01% and 0.02% benzalkonium chloride. Direct correlation proportion was found out between the surface tension and the weight of the drops. When the dispensing angle decreased from 90ř to 45řthe weight of the drops significantly decreased too. When the dropper tip was wetted the effective circuit of the dropper tip produced larger drops increasing variability of drop weigth together with the amout of applied drugs. Out of dropper systems tested, we can conclude that the lowest...
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Vývoj umělého zubu založený na technice povrchové plasmové resonance
Solanská, Kateřina ; Polášek, Miroslav (referee) ; Solich, Petr (advisor)
For development an artificial tooth hydroxyapatite nanoparticles solution was electrophoretically deposited on the gold chip. It was established that experimental conditions of solution preparation, electrically field have marked effect to thickness of the hydroxyapatite layer. By this way was prepared chip suitable for SPR measurements. In the firs step the bovine serum albumin (BSA) was chosen as the model protein shows absorption on the hydroxyapatite layer. Further the native saliva and artificial saliva were used for pellicle forming. Samples of saliva showed difference between binding behaviors on the hydroxyapatite layer. The application of chlorhexidingluconate pharmaceuticals on the pellicle shows increase in thickness but rinsing with native saliva disclosed that the components of chlorhexidingluconate pharmaceuticals can be easily removed from the surface.
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