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National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
Background innate reflex locomotion patterns of movement and ventilation in children patients with chronic respiratory diseases
 Plešková, Jana ; Pohunek, Petr (advisor) ; Sedlák, Vratislav (referee) ; Homola, Lukáš (referee)
Reflex locomotion according to Professor Vojta (VRL) is based on the activation of complex motor patterns from certain defined positions with stimulation of the so-called trigger zones, located on the human's body. It is primarily used in patients with neurological deficits; however, it is currently also being used in internal medicine. It has been reported that VRL can indirectly affect breathing, however its use in paediatric patients with chronic respiratory disease has not yet been investigated. As part of this theses, a randomized controlled single-centre intervention study was conducted. Its aim was to evaluate the short-term effects of VRL on lung function in paediatric patients with cystic fibrosis (CF) with normal baseline spirometry. The effect of a 30minute VRL intervention was compared in a crossover design with the effect of positioning (without stimulation of trigger zones). The primary outcome was the change in global ventilation inhomogeneity, assessed by lung clearance index (LCI2.5) derived from nitrogen multiple breath washout test. Secondary outcomes included changes in regional ventilation inhomogeneity (indices of acinar [Sacin*Vt] and conductive airways [Scond*Vt] inhomogeneity) and spirometric parameters (inspiratory capacity, forced vital capacity, and forced expiratory...
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Monitoring of airway inflammation in patients with various types of bronchial obstructionMonitoring of oxidative stress biomarkers in exhaled breath condensate of patients with severe refractory asthma
 Sedlák, Vratislav ; Salajka, František (advisor) ; Skřičková, Jana (referee) ; Panzner, Petr (referee)
Monitoring of airway inflammation in patients with various types of bronchial obstruction. Monitoring of oxidative stress biomarkers in exhaled breath condensate of patients with severe refractory asthma. Background: Asthma is chronic inflammatory disease associated with bronchial hyperreactivity. Various cells plays and cellular products are involved in asthma pathogenesis. Oxidative stress plays also a significant role in mechanisms of asthma via action of reactive oxygen (ROS) and nitrogen (NOS) species. These free radicals develop from inflammatory airway reaction and from exogenous exposure of air-pollution (ozone, cigarette smoke). ROS and NOS and its products cause damage of bio- membranes, proteins and nucleic acid. Several studies showed correlation of asthma severity to intensity of oxidative stress. Aim of the study: The main goal of the study was to describe differences in concentrations of various markers of oxidative stress in exhaled breath condensate of severe refractory asthma (SRA) patients and healthy controls (HC). Secondary aim was to show correlation of oxidative stress intensity to severity of eosinophilic inflammation described by peripheral blood eosinophilia or exhaled nitric oxide concentration. Methodology: We harvested exhaled breath condensate in 40 SRA patients and 19...
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See also: similar author names
2 Sedlák, Vladimír
1 Sedlák, Vojtěch
4 Sedlák, Václav
2 Sedlák, Vít
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