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General Anesthesia and Analgosedation with Combination of new Alfa2 agonists and ketamine - focused on specific situation
Schreiberová, Jitka ; Černý, Vladimír (advisor) ; Cvachovec, Karel (referee) ; Málek, Jiří (referee)
Introduction: Ideally, general anesthesia and analgosedation in specific situations should meet the following requirements: fast and simple induction of analgesia, achievement of the desired suppression of consciousness, minimal cardiovascular effects, preservation of patent airways without the need for mandatory ventilation, and rapid recovery after the application of antagonists. Ketamine is widely used for this purpose, often in combination with benzodiazepines, however, it does possess an undesired psychomimetic effect and lacks a specific antagonist. In veterinary anesthesia ketamine is often used in combination with alfa2 agonists, a group of substances with a favourable pharmacological profile in specific situations from an anesthesiologist's point of view. Ketamine in combination with new representatives of alfa2 agonists may theoretically be a promising new option for this purpose. Aim: In rhesus monkeys experiments to assess 1. immobilization by combination of ketamine with alfa2 agonists, 2. effect of the addition of hyaluronidase to the above mentioned combinations, and 3. the possibility of reducing ketamine dosage through the addition of a small dose of midazolam while maintaining the effect of immobilization. In the clinical part to assess analgosedation with combination of...
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