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Treatment of peptic ulcer
Sakač, Jiří ; Tilšer, Ivan (advisor) ; Hrdina, Radomír (referee)
Topic: Treatment of peptic ulcers Autor: Jiří Sakač Peptic ulcers represent one of the most widespread gastrointestinal disease all over the world. It occurs the most in the middle and high aged people. It is a multifactorial disease, which is developed by dysbalanc between agresive and protective factors. Its occurrence and incidence is associated with presence of the infection Helicobacter pylori in gastrointestinal tract. H. pylori is the main risk faktor for a diverse spectrum of gastrointestinal diseases, and it makes first damage of mucous membrane. Comprehensive individual treatment consist of non-pharmacological lifestyle modification and pharmacological treatment. In the treatment, there are used drugs, which inhibite secretions of the agresive hydrochloric acid (H2-receptor antagonist, proton pumps inhibitors), cytoprotective drugs (sucralfat, bismut`s salts, syntetic analogs of prostaglandins) and drugs for eradication of H. pylori - antibiotics and chemoterapeutics. Accurate diagnosis, timely and efective treatment reduce a risk of recurrence and the complications; which can endanger patient's life (bleeding, penetration, perforation); and they can accelerate final healing most of the ulcers.
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Treatment of peptic ulcer
Sakač, Jiří ; Hrdina, Radomír (referee) ; Tilšer, Ivan (advisor)
Topic: Treatment of peptic ulcers Autor: Jiří Sakač Peptic ulcers represent one of the most widespread gastrointestinal disease all over the world. It occurs the most in the middle and high aged people. It is a multifactorial disease, which is developed by dysbalanc between agresive and protective factors. Its occurrence and incidence is associated with presence of the infection Helicobacter pylori in gastrointestinal tract. H. pylori is the main risk faktor for a diverse spectrum of gastrointestinal diseases, and it makes first damage of mucous membrane. Comprehensive individual treatment consist of non-pharmacological lifestyle modification and pharmacological treatment. In the treatment, there are used drugs, which inhibite secretions of the agresive hydrochloric acid (H2-receptor antagonist, proton pumps inhibitors), cytoprotective drugs (sucralfat, bismut`s salts, syntetic analogs of prostaglandins) and drugs for eradication of H. pylori - antibiotics and chemoterapeutics. Accurate diagnosis, timely and efective treatment reduce a risk of recurrence and the complications; which can endanger patient's life (bleeding, penetration, perforation); and they can accelerate final healing most of the ulcers.
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