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Neurogenetický potenciál kmenových buněk u myší
Slabá, Barbora ; Štaud, František (advisor) ; Červený, Lukáš (referee)
Neural stem cells (NSCs) are present in the mammalian adult nervous system and are found in two specific regions: the subventricular zone of the forebrain and the subgranular zone in the dentate gyrus of the hippocampus. NSCs undergo fate specification, maturation and functional integration before they can take part in neuronal circuits. Less is known about the mechanisms controlling these processes or the function of the newly born neurons in the adult brain. A large number of molecular and environmental factors can regulate various aspects of proliferation, maturation and differentiation of adult stem cells in adult nervous system. NSCs can give rise to three main types of neural cells: neurons, astrocytes and oligodendrocytes. It is suggested that astrocytes may play critical role in regulating neurogenesis in both the intact adult brain and after injury. Therefore, determining how astrocytes regulate adult neurogenesis at the molecular level is an essential step toward understanding the regulation of adult neurogenesis. To find out how genetic alteration of astrocytic intermediate filament will affect neural stem cells of postnatal mice, the neurosphere assay was performed in order to compare the proliferative and differentiation characteristics of neural stem/progenitor cells in GFAP-/- Vim-/-...
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Neurogenetický potenciál kmenových buněk u myší
Slabá, Barbora ; Červený, Lukáš (referee) ; Štaud, František (advisor)
Neural stem cells (NSCs) are present in the mammalian adult nervous system and are found in two specific regions: the subventricular zone of the forebrain and the subgranular zone in the dentate gyrus of the hippocampus. NSCs undergo fate specification, maturation and functional integration before they can take part in neuronal circuits. Less is known about the mechanisms controlling these processes or the function of the newly born neurons in the adult brain. A large number of molecular and environmental factors can regulate various aspects of proliferation, maturation and differentiation of adult stem cells in adult nervous system. NSCs can give rise to three main types of neural cells: neurons, astrocytes and oligodendrocytes. It is suggested that astrocytes may play critical role in regulating neurogenesis in both the intact adult brain and after injury. Therefore, determining how astrocytes regulate adult neurogenesis at the molecular level is an essential step toward understanding the regulation of adult neurogenesis. To find out how genetic alteration of astrocytic intermediate filament will affect neural stem cells of postnatal mice, the neurosphere assay was performed in order to compare the proliferative and differentiation characteristics of neural stem/progenitor cells in GFAP-/- Vim-/-...
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The complex development of accompanying infrastructure of tourism in Hlubocko area
SLABÁ, Barbora
This thesis deals with the comprehensive development of accompanying infrastructure for sports and recreational activities. The aim is to analyze the supply and demand of tourism in Hlubocko area. An increased emphasis is placed on analysis accompanying infrastructure for leisure time activities. At the end of this work are presented a suggestions and recommendations on modernization of accompanying infrastructure to improve comfort, safety and technical standard of sports and recreational facilities in the investigated area. Furthermore is presented design of ideal tourism product with regard to the requirements and wishes of visitors, based on research and structured interviews.
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A usages of industrial heritage in tourism development on case of water mill "Hoslovice"
SLABÁ, Barbora
This Bachelor's thesis deals with the use of technical monuments water mill Hoslovice in the development of tourism. The aim was the implement situatioan analysis in Strakonice region and find out segments of tourist visiting this area. On the basis of the marketing survey, that took place on the technical monuments have been selected segment of visitors. At the end of this work are presented a suggestions complement and innovation the tourism product in Hoslovice.
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