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National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
Atypická distribuce neuropeptidu corazoninu v buňkách kruhové žlázy u larev \kur{Drosophila melanogaster} s mutací v adipokinetickém hormonu
 SLÁDKOVÁ, Kristýna
Adipokinetic hormone (Akh) is an insect neuropeptide produced by the neuroendocrine gland of the corpora cardiaca and is involved in mobilization of energy stores and associated biochemical and physiological changes. In the Akh1 mutant line of the fruitfly, Drosophila melanogaster with a deletion of the second amino acid (Leu), an atypical localization of the neuropeptide corazonin (Crz) was observed. Crz is present in Akh-positive cells in the ring gland of the larval brain, indicating a possible representation of non-functional Akh1 by this phylogenetically related peptide. However, the connection of Crz expression in corpora cardiaca cells with a mutation in the receptor for Akh, Crz and sulphonylurea (i.e. components that are expected to be involved at different levels in the Akh signaling pathway) has not been demonstrated. Since this atypical distribution of Crz has not been confirmed in mutants with a null Akh mutation, the detected changes in the distribution of Crz in Akh1 mutants can be explained by the possible cross-reactivity of the anti-Crz antibody with Akh1 peptide. The possibility of cross-reactivity tested on a nitrocellulose membrane did not confirm this hypothesis, therefore the specific role of Crz in Akh1 mutants cannot be completely ruled out.
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Elektrofyziologické studie geneticky kódované sondy napětí ArcLight
 SLÁDKOVÁ, Kristýna
Electrical signals are a hallmark of neuronal aktivity. In order to understand how the brain works, we need to be able to visualize the electrical signals. A promising way to observe the electrical signals in neurons involves using a voltage sensitive fluorescent protein and an optical microscope. One of the best voltage sensitive fluorescent proteins is ArcLight. The aim of this work was to investigate the molecular mechanism of the function of this construct. First, this work describes methods for measuring membrane potential and associated changes in fluorescence intensity. The last part presents the results of our microscopic observation.
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See also: similar author names
15 SLÁDKOVÁ, Kateřina
15 Sládková, Kateřina
1 Sládková, Klára
1 Sládková, Klára Lily
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