|
|
The role of voltage-gated calcium channels in mammalian adipose cells
Pěknicová, Zuzana ; Ryšková, Lucie (advisor) ; Vlachová, Viktorie (referee)
Fat cells (adipocytes) are important regulators of adipose tissue and the whole organism. These cells are actively involved in whole-body energy homeostasis and changes in their function and metabolism have a far-reaching impact on an individual's health. Understanding the molecular mechanisms that orchestrate the proper functioning of adipocyte cellular processes can significantly aid in the treatment of a number of diseases including obesity, type II diabetes, and others. Therefore, considerable effort is currently being devoted to investigating the various signaling pathways involved in the life of a healthy adipocyte. Calcium, or its active form Ca2+, is an essential tool for cellular signal transduction and triggers a several biologically important processes in most cell types, including adipocytes. This bachelor thesis focuses on the regulation of calcium homeostasis by voltage-gated calcium channels, which appear to be active in the adipocyte, even though it is generally a non-excitable tissue. This paper summarizes current knowledge on the type, structure and function of calcium channels and their effects on adipocyte (patho)physiology. Possible therapeutic benefits based on the regulation of selected calcium channels as potential targets for the treatment of metabolic disorders are also...
|
|
|
Motivation of employees in language schools
Rysková, Lucie ; Legnerová, Kateřina (advisor) ; Hudíková, Jana (referee)
My bachelor thesis is focused on problems of the working motivation of employees in two selected companies. The aim of the work is to analyze and evaluate the current situation of motivational system of language school's employees and to find potential recommendations which could help. The work is divided into theoretical and practical part. Theoretical part devotes to defining the term motivation with emphasis on motivation of working behaviour and other basic related knowledge. In practical part, there is description of the research's aims, chosen method, analysis and evaluation. Data were acquired by questionnaire which included several circuits of questions regarding inside communication and relationships, career progression, employee engagement or job description.
|
guest ::
RSS feed.