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National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
Plasticized polymeric systems with salicylic acid
 Rychterová, Gabriela ; Šnejdrová, Eva (advisor) ; Dittrich, Milan (referee)
1 ABSTRAKT CHARLES UNIVERSITY IN PRAGUE Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical technology Name of the student: Gabriela Rychterová Title of diploma thesis: Plasticized polymeric systems with salicylic acid Consultant: PharmDr. Eva Šnejdrová, Ph.D. The thermal and released characteristics of solid dispersions are studied and evaluated in this thesis. The copolymers of lactic and glycolic acid branched on the central molecule of tripentaerythritol were used as carrier. Salicylic acid were incorporated by solvent method using methyl formate and melting method. The theoretical part is focused on the characterization of the plasticizers (their efficiency, properties, toxicity, selection criteria, classification and biocompatibility) and the study of the solid dispersions (classification, mechanism of drug release, applications). The solvent method and evaporation employing the methyl formate is considered as suitable method of preparation of the solid dispersions with the higher content of salicylic acid. The results of the thermal analysis show that the drug is molecularly dispersed in the polymer. In concentrations from 5 % to 20 % salicylic acid possess the plasticizing effect. Methyl salicylate is employed as multifunctional plasticizer with decreasing effect on Tg and also serves...
Detailed record
Plasticized polymeric systems with salicylic acid
 Rychterová, Gabriela ; Šnejdrová, Eva (advisor) ; Dittrich, Milan (referee)
1 ABSTRAKT CHARLES UNIVERSITY IN PRAGUE Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical technology Name of the student: Gabriela Rychterová Title of diploma thesis: Plasticized polymeric systems with salicylic acid Consultant: PharmDr. Eva Šnejdrová, Ph.D. The thermal and released characteristics of solid dispersions are studied and evaluated in this thesis. The copolymers of lactic and glycolic acid branched on the central molecule of tripentaerythritol were used as carrier. Salicylic acid were incorporated by solvent method using methyl formate and melting method. The theoretical part is focused on the characterization of the plasticizers (their efficiency, properties, toxicity, selection criteria, classification and biocompatibility) and the study of the solid dispersions (classification, mechanism of drug release, applications). The solvent method and evaporation employing the methyl formate is considered as suitable method of preparation of the solid dispersions with the higher content of salicylic acid. The results of the thermal analysis show that the drug is molecularly dispersed in the polymer. In concentrations from 5 % to 20 % salicylic acid possess the plasticizing effect. Methyl salicylate is employed as multifunctional plasticizer with decreasing effect on Tg and also serves...
Detailed record

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