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The effect of rice extract on the compressibility and mechanical properties of microcrystalline cellulose tablets.
Rumlerová, Lenka ; Ondrejček, Pavel (advisor) ; Mužíková, Jitka (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of: Department of Pharmaceutical Technology Consultant: PharmDr. Pavel Ondrejček, Ph.D Student: Lenka Rumlerová Title of Thesis: The effect of rice extract on the compressibility and mechanical properties of microcrystalline cellulose tablets. This thesis deals with influence of rice extract, as a new kind of glidant on compressibility of microcrystalline celulose as a model filler. Furthermore it evaluates the impact of rice extract on tablet properties. Effects of rice extract were compared with two standard glidants - magnesium stearate and colloidal silicon dioxide. As first the influence of diferent glidants concetrations on flow properties of mixtures were assesed. Tablets were compresed using three different compression forces. A force- displacement record was used to evaluate the compressibility of microcrystalline cellulose and its mixtures with glidants. Subsequently, the properties of tablets were evaluated. The radial strenght, abrasion, and tablet disintegration time were measured. The results revealed that the rice extract has the least effect on mixtures flow poperties. However, all mixtures showed a statistically significant improvement in flowability. When using a 1 % rice extract, the flow properties of the...
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The effect of rice extract on the compressibility and mechanical properties of microcrystalline cellulose tablets.
Rumlerová, Lenka ; Ondrejček, Pavel (advisor) ; Mužíková, Jitka (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of: Department of Pharmaceutical Technology Consultant: PharmDr. Pavel Ondrejček, Ph.D Student: Lenka Rumlerová Title of Thesis: The effect of rice extract on the compressibility and mechanical properties of microcrystalline cellulose tablets. This thesis deals with influence of rice extract, as a new kind of glidant on compressibility of microcrystalline celulose as a model filler. Furthermore it evaluates the impact of rice extract on tablet properties. Effects of rice extract were compared with two standard glidants - magnesium stearate and colloidal silicon dioxide. As first the influence of diferent glidants concetrations on flow properties of mixtures were assesed. Tablets were compresed using three different compression forces. A force- displacement record was used to evaluate the compressibility of microcrystalline cellulose and its mixtures with glidants. Subsequently, the properties of tablets were evaluated. The radial strenght, abrasion, and tablet disintegration time were measured. The results revealed that the rice extract has the least effect on mixtures flow poperties. However, all mixtures showed a statistically significant improvement in flowability. When using a 1 % rice extract, the flow properties of the...
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