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National Repository of Grey Literature 2 records found  Search took 0.01 seconds. 
The effect of acetylcholinesterase reactivators on urinary bladder contraction
 Rambousková, Lucia ; Vopršalová, Marie (advisor) ; Herink, Josef (referee)
Candidate: Mgr. Lucia Rambousková Title of thesis: The effect of acetylcholinesterase reactivators on urinary bladder contraction Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Supervisor: PharmDr. Marie Vopršálová, CSc. Consultant specialist: PharmDr. Vendula Šepsová, Ph.D Acetylcholinesterase (AChE) reactivators major mechanism is attributed to their ability to reactivate phosporylated enzyme, AChE. It has been thought that oxime might have additional direct pharmacological effect, other than AChE reactivation. The oximes may exert effects by interaction with cholinergic receptors. The most of them have antiniconitic or antimuscarinic properties, thus they protect against higher concentration of acetylcholine. The aim of this study was to evaluate the effect of reactivators K 203 and K 027. A contraction study on the rat urinary bladder has been chosen to investigate effect on muscarinic and purinergic receptors. Isolated strips of urinary bladder in the organ bath were used. There were three types of stimulation - electric stimulation (EFS), muscarinic receptor agonist methacholine (MCh) and purinergic receptor agonist adenosine triphosphate (ATP). In conclusion oxime K 027 has tendency to reduce the contraction (during EFS and MCh...
Detailed record
The effect of acetylcholinesterase reactivators on urinary bladder contraction
 Rambousková, Lucia ; Vopršalová, Marie (advisor) ; Herink, Josef (referee)
Candidate: Mgr. Lucia Rambousková Title of thesis: The effect of acetylcholinesterase reactivators on urinary bladder contraction Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Supervisor: PharmDr. Marie Vopršálová, CSc. Consultant specialist: PharmDr. Vendula Šepsová, Ph.D Acetylcholinesterase (AChE) reactivators major mechanism is attributed to their ability to reactivate phosporylated enzyme, AChE. It has been thought that oxime might have additional direct pharmacological effect, other than AChE reactivation. The oximes may exert effects by interaction with cholinergic receptors. The most of them have antiniconitic or antimuscarinic properties, thus they protect against higher concentration of acetylcholine. The aim of this study was to evaluate the effect of reactivators K 203 and K 027. A contraction study on the rat urinary bladder has been chosen to investigate effect on muscarinic and purinergic receptors. Isolated strips of urinary bladder in the organ bath were used. There were three types of stimulation - electric stimulation (EFS), muscarinic receptor agonist methacholine (MCh) and purinergic receptor agonist adenosine triphosphate (ATP). In conclusion oxime K 027 has tendency to reduce the contraction (during EFS and MCh...
Detailed record

See also: similar author names
3 RAMBOUSKOVÁ, Lucie
2 Rambousková, Ladislava
3 Rambousková, Lenka
3 Rambousková, Lucie
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