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A study of directly compressible tableting materials with the combination of chitosan and silicified microcrystalline cellulose.
Rabasová, Markéta ; Mužíková, Jitka (advisor) ; Šnejdrová, Eva (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department: Pharmaceutical Technology Student: Markéta Rabasová Consultant: Assoc. Prof. PharmDr. Jitka Mužíková, Ph.D. Title of the Diploma Thesis: A study of directly compressible tableting materials with the combination of chitosan and silicified microcrystalline cellulose This thesis deals with the study of compressibility of directly compressible tableting materials with chitosan and silicified microcrystalline cellulose Prosolv® SMCC 90 in a ratio of 3:1, their lubricant sensitivity and the tensile strength of tablets. Retardant components of the tableting materials are sodium alginate in concentrations of 30, 40 and 50 % or its combinations with hypromellose 15M in a ratio of 1:1 in the same concentrations. Magnesium stearate in a concentration of 1 % is used as a lubricant, indomethacin in a concentration of 20 % is used as a model drug. Tablets without the lubricant and the drug are compressed by compression forces of 3, 3,5 and 4 kN, tablets with the lubricant and the drug are compressed by compression force of 4 kN. T1-FRO 50 Zwick/Roell material testing equipment is used for the compression of the tablets. The compressibility is evaluated by the energy profile of the compression process, the lubricant sensitivity is evaluated by...
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A study of directly compressible tableting materials with the combination of chitosan and silicified microcrystalline cellulose.
Rabasová, Markéta ; Mužíková, Jitka (advisor) ; Šnejdrová, Eva (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department: Pharmaceutical Technology Student: Markéta Rabasová Consultant: Assoc. Prof. PharmDr. Jitka Mužíková, Ph.D. Title of the Diploma Thesis: A study of directly compressible tableting materials with the combination of chitosan and silicified microcrystalline cellulose This thesis deals with the study of compressibility of directly compressible tableting materials with chitosan and silicified microcrystalline cellulose Prosolv® SMCC 90 in a ratio of 3:1, their lubricant sensitivity and the tensile strength of tablets. Retardant components of the tableting materials are sodium alginate in concentrations of 30, 40 and 50 % or its combinations with hypromellose 15M in a ratio of 1:1 in the same concentrations. Magnesium stearate in a concentration of 1 % is used as a lubricant, indomethacin in a concentration of 20 % is used as a model drug. Tablets without the lubricant and the drug are compressed by compression forces of 3, 3,5 and 4 kN, tablets with the lubricant and the drug are compressed by compression force of 4 kN. T1-FRO 50 Zwick/Roell material testing equipment is used for the compression of the tablets. The compressibility is evaluated by the energy profile of the compression process, the lubricant sensitivity is evaluated by...
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