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National Repository of Grey Literature 2 records found  Search took 0.01 seconds. 
Development of the rat circadian system under constant light conditions
 Petrželková, Lucie ; Bendová, Zdeňka (advisor) ; Kopřivová, Jana (referee)
The circadian system is a mechanism designed to generate circadian time and to synchronize it with the solar cycle. Its function is to adjust to behavioral and physiological function with the 24-hour period. The adjustment is performed using a so-called zeitgeber or synchronizer. The main circadian clock is in the suprachiasmatic nuclei (SCN) in the hypothalamus. Prolonged exposure of the organism to constant light conditions results in desynchronization of the circadian clock, which can lead to many pathologies. The impact of light at night on the organism has been studied for a long time, but the question of the impact of constant light on the development of the circadian system of the organism has been less studied. My thesis deals with this issue. Using RT-qPCR I investigated how the rhytm changes in the expression of selected clock genes in selected parts of the rat's brain, which has been kept in constant light sice birth. I also tested the impact of exposure to constant light on the early development of rhytm in locomotor activity later in the rat's life. Keywords: circadian system, photic entrainment, desynchronization under constant light, development, rat
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Consequences of desynchronization of the circadian system by constant light
 Petrželková, Lucie ; Bendová, Zdeňka (advisor) ; Honzlová, Petra (referee)
The circadian clock exists in every organism and their period is approximately 24 hours. This circadian rhythm is maintained even in a completely non-periodic environment but must be adapted to a precise 24-hour solar cycle using a synchronizer, called zeitgeber. The main controlling organ of the circadian rhythm are the suprachiasmatic nuclei (SCN) in the ventral hypothalamus. There are also peripheral clocks, for example in the liver or lungs. These peripheral clocks operate autonomously but the SCNs synchronize them with their own period and phase. The most important zeitgeber is the light and dark alternation. This bachelor thesis describes the consequences of conditions where there is no regular light and dark alternation and constant light conditions are established instead. Constant light can disturb the circadian rhythm and desynchronize the circadian clocks. This bachelor thesis summarizes the scientific knowledge of desynchronization by the effect of constant light and briefly describes the selected pathologies resulting from the desynchronization of the circadian system. Selected pathologies include ovarian tumour and breast cancer, obesity and insulin resistance, immunosenescense and schizophrenia. Key words constant light, circadian system, suprachiasmatic nucleus
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3 Petrželková, Lenka
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