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National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
Forced degradation studies of dimethindene maleate using HPLC
 Pannyová, Anna ; Chocholoušová Havlíková, Lucie (advisor) ; Kujovská Krčmová, Lenka (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Analytical Chemistry Student: Anna Pannyová Supervisor: PharmDr. Lucie Havlíková, Ph.D. Title of diploma thesis: Forced degradation studies of dimethindene maleate using HPLC The aims of this thesis were to perform forced degradation of dimethindene maleate and to optimize the chromatographic conditions for the determination of dimethindene maleate and its related compounds. The stress testing was conducted with drug product/drug in order to exam its stability. Decomposition of the product can lead to loss of the content of the active substance, loss of their pharmacological activity or forming of degradation products. Dimethindene maleate is an antihistamine drug. He affects H1 histamine receptors. Nowadays, high performance liquid chromatography (HPLC) is one of the most used separation techniques for the determination of the drug stability. The stability of dimethindene maleate was investigated using stress testing (forced degradation studies). Dimethindene was stable in aqueous and acid solution as well as under heating (70řC). Significant degradation was observed when the drug was subjected to basic and oxidation stress conditions; this led to the formation of two degradation products DP1 and DP2 (described using...
Detailed record
Forced degradation studies of dimethindene maleate using HPLC
 Pannyová, Anna ; Chocholoušová Havlíková, Lucie (advisor) ; Kujovská Krčmová, Lenka (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Analytical Chemistry Student: Anna Pannyová Supervisor: PharmDr. Lucie Havlíková, Ph.D. Title of diploma thesis: Forced degradation studies of dimethindene maleate using HPLC The aims of this thesis were to perform forced degradation of dimethindene maleate and to optimize the chromatographic conditions for the determination of dimethindene maleate and its related compounds. The stress testing was conducted with drug product/drug in order to exam its stability. Decomposition of the product can lead to loss of the content of the active substance, loss of their pharmacological activity or forming of degradation products. Dimethindene maleate is an antihistamine drug. He affects H1 histamine receptors. Nowadays, high performance liquid chromatography (HPLC) is one of the most used separation techniques for the determination of the drug stability. The stability of dimethindene maleate was investigated using stress testing (forced degradation studies). Dimethindene was stable in aqueous and acid solution as well as under heating (70řC). Significant degradation was observed when the drug was subjected to basic and oxidation stress conditions; this led to the formation of two degradation products DP1 and DP2 (described using...
Detailed record

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