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The adhesive properties of the oligoesters of lactic acid and glycolic acid branched with dipentaerythritol
Páblová, Sylva ; Šnejdrová, Eva (advisor) ; Dittrich, Milan (referee)
The theoretical part of this rigorous theses describes concept of bioadhesion in the drug administration and characterizes some of basal ways of the drug administration (oral, peroral, ophthalmic, nasal, vaginal). It also specifies the bioadhesive dosage forms in use. The aim of the experiment was to study the adhesiveness of with dipentaerythritol branched D,L-lactic and glycolic acid oligoesters using Material testing machine Zwick/Roell T1- FR050TH.A1K. The maximum force (Fmax) required to detaching the polymer systems from substrate was measured for determination of the adhesiveness of the oligoesters. Rheological properties were measured using Brookfield digital viscosimeter DV-E. It was found that Fmax of the branched oligoesters decreases with growing molecular weight and branch level. Adhesiveness of samples on the non-stick base: PLGA, 0,5D and 1D were approximately the same, 2D was of lower value. The numbers of on the pig ear base measurement were multiple lower. There was a decrease of viscosity of the adhesive polymers in the order: PLGA, 0,5D, 1D, 2D.
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Adhesive force measurement of oligoester carriers
Páblová, Sylva ; Šnejdrová, Eva (advisor) ; Dittrich, Milan (referee)
The aim of this graduation theses was to study the adhesiveness of branched oligoesters under various testing conditions using Material testing machine Zwick/Roell T1-FR050TH.A1K and rheological properties using Brookfield digital viscosimeter DV-E. The maximum force (Fmax) required to detaching the polymer systems from substrate was measured for determination of adhesiveness of oligoesters. It was found that Fmax of branched oligoesters was significantly higher in comparison with Carbomera or Methylcellulose hydrogels. The increase of the maximal adhesive force is due to the growing consolidation force, the contact time and sample detachment velocity. There was a decrease of the viscosity of the adhesive polymers caused by increasing concentration of the branching component. The incorporation of the drug had a different effect on the viscosity of the various samples. The swelling of the adhesive polymers led to the decrease of the viscosity.
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Adhesive force measurement of oligoester carriers
Páblová, Sylva ; Šnejdrová, Eva (advisor) ; Dittrich, Milan (referee)
The aim of this graduation theses was to study the adhesiveness of branched oligoesters under various testing conditions using Material testing machine Zwick/Roell T1-FR050TH.A1K and rheological properties using Brookfield digital viscosimeter DV-E. The maximum force (Fmax) required to detaching the polymer systems from substrate was measured for determination of adhesiveness of oligoesters. It was found that Fmax of branched oligoesters was significantly higher in comparison with Carbomera or Methylcellulose hydrogels. The increase of the maximal adhesive force is due to the growing consolidation force, the contact time and sample detachment velocity. There was a decrease of the viscosity of the adhesive polymers caused by increasing concentration of the branching component. The incorporation of the drug had a different effect on the viscosity of the various samples. The swelling of the adhesive polymers led to the decrease of the viscosity.
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The adhesive properties of the oligoesters of lactic acid and glycolic acid branched with dipentaerythritol
Páblová, Sylva ; Šnejdrová, Eva (advisor) ; Dittrich, Milan (referee)
The theoretical part of this rigorous theses describes concept of bioadhesion in the drug administration and characterizes some of basal ways of the drug administration (oral, peroral, ophthalmic, nasal, vaginal). It also specifies the bioadhesive dosage forms in use. The aim of the experiment was to study the adhesiveness of with dipentaerythritol branched D,L-lactic and glycolic acid oligoesters using Material testing machine Zwick/Roell T1- FR050TH.A1K. The maximum force (Fmax) required to detaching the polymer systems from substrate was measured for determination of the adhesiveness of the oligoesters. Rheological properties were measured using Brookfield digital viscosimeter DV-E. It was found that Fmax of the branched oligoesters decreases with growing molecular weight and branch level. Adhesiveness of samples on the non-stick base: PLGA, 0,5D and 1D were approximately the same, 2D was of lower value. The numbers of on the pig ear base measurement were multiple lower. There was a decrease of viscosity of the adhesive polymers in the order: PLGA, 0,5D, 1D, 2D.
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